PMID- 26548809
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20220318
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 162
DP  - 2016 Feb
TI  - Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic 
      Retinopathy Using Swept-Source Optical Coherence Tomography.
PG  - 140-149.e1
LID - S0002-9394(15)00680-7 [pii]
LID - 10.1016/j.ajo.2015.10.025 [doi]
AB  - PURPOSE: To analyze the vitreoretinal interface in diabetic eyes using 
      3-dimensional wide-field volumes acquired using high-speed, long-wavelength 
      swept-source optical coherence tomography (SSOCT). DESIGN: Prospective 
      cross-sectional study. METHODS: Fifty-six diabetic patients (88 eyes) and 11 
      healthy nondiabetic controls (22 eyes) were recruited. Up to 8 SSOCT volumes were 
      acquired for each eye. A registration algorithm removed motion artifacts and 
      merged multiple SSOCT volumes to improve signal. Vitreous visualization was 
      enhanced using vitreous windowing method. RESULTS: Of 88 diabetic eyes, 20 eyes 
      had no retinopathy, 21 eyes had nonproliferative diabetic retinopathy (NPDR) 
      without macular edema, 20 eyes had proliferative diabetic retinopathy (PDR) 
      without macular edema, and 27 eyes had diabetic macular edema (DME) with either 
      NPDR or PDR. Thick posterior hyaloid relative to healthy nondiabetic controls was 
      observed in 0 of 20 (0%) diabetic eyes without retinopathy, 4 of 21 (19%) eyes 
      with NPDR, 11 of 20 (55%) eyes with PDR, and 11 of 27 (41%) eyes with DME (P = 
      .0001). Vitreoschisis was observed in 6 of 22 (27%) healthy nondiabetic eyes, 9 
      of 20 (45%) diabetic eyes without retinopathy, 10 of 21 (48%) eyes with NPDR, 13 
      of 20 (65%) eyes with PDR, and 17 of 27 (63%) eyes with DME (P = .007). While no 
      healthy nondiabetic controls and diabetic eyes without retinopathy had 
      adhesions/pegs between detached posterior hyaloid and retina, 1 of 21 (4%), 11 of 
      20 (55%), and 11 of 27 (41%) eyes with NPDR, PDR, and DME, respectively, 
      demonstrated this feature (P = .0001). CONCLUSION: SSOCT with motion-correction 
      and vitreous windowing provides wide-field 3-dimensional information of 
      vitreoretinal interface in diabetic eyes. This may be useful in assessing 
      progression of retinopathy, planning diabetic vitreous surgery, and predicting 
      treatment outcomes.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Adhi, Mehreen
AU  - Adhi M
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts; Departments of Electrical Engineering and Computer Science and 
      Research Laboratory of Electronics, Massachusetts Institute of Technology, 
      Cambridge, Massachusetts.
FAU - Badaro, Emmerson
AU  - Badaro E
AD  - Department of Ophthalmology, Federal University of Brazil, Sao Paulo, Brazil.
FAU - Liu, Jonathan J
AU  - Liu JJ
AD  - Departments of Electrical Engineering and Computer Science and Research 
      Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, 
      Massachusetts.
FAU - Kraus, Martin F
AU  - Kraus MF
AD  - Pattern Recognition Lab and School of Advanced Optical Technologies (SAOT), 
      University Erlangen-Nuremberg, Erlangen, Germany.
FAU - Baumal, Caroline R
AU  - Baumal CR
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts.
FAU - Witkin, Andre J
AU  - Witkin AJ
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts.
FAU - Hornegger, Joachim
AU  - Hornegger J
AD  - Pattern Recognition Lab and School of Advanced Optical Technologies (SAOT), 
      University Erlangen-Nuremberg, Erlangen, Germany.
FAU - Fujimoto, James G
AU  - Fujimoto JG
AD  - Departments of Electrical Engineering and Computer Science and Research 
      Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, 
      Massachusetts.
FAU - Duker, Jay S
AU  - Duker JS
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts.
FAU - Waheed, Nadia K
AU  - Waheed NK
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts. Electronic address: nadiakwaheed@gmail.com.
LA  - eng
GR  - R01 CA075289/CA/NCI NIH HHS/United States
GR  - R01 EY011289/EY/NEI NIH HHS/United States
GR  - R01 EY013178/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151106
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2016 May;165:208. PMID: 27041099
CIN - Am J Ophthalmol. 2016 May;165:208-9. PMID: 27056110
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/*diagnosis
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Imaging, Three-Dimensional
MH  - Macular Edema/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Vitreous Body/*pathology
MH  - Vitreous Detachment/*diagnosis
PMC - PMC4911896
MID - NIHMS736060
EDAT- 2015/11/10 06:00
MHDA- 2016/06/21 06:00
PMCR- 2017/02/01
CRDT- 2015/11/10 06:00
PHST- 2015/02/02 00:00 [received]
PHST- 2015/10/29 00:00 [revised]
PHST- 2015/10/29 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - S0002-9394(15)00680-7 [pii]
AID - 10.1016/j.ajo.2015.10.025 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2016 Feb;162:140-149.e1. doi: 10.1016/j.ajo.2015.10.025. Epub 
      2015 Nov 6.