PMID- 26549004
OWN - NLM
STAT- MEDLINE
DCOM- 20161010
LR  - 20161230
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 1
DP  - 2016
TI  - Elevated Cardiac Enzymes in Hypertrophic Cardiomyopathy Patients With Heart 
      Failure - A 20-Year Prospective Follow-up Study.
PG  - 218-26
LID - 10.1253/circj.CJ-15-0872 [doi]
AB  - BACKGROUND: To better understand the evolution of typical hypertrophic 
      cardiomyopathy (HCM) to heart failure (HF), we investigated the relationship 
      between serum biochemical abnormalities and changes in left ventricular (LV) 
      remodeling. METHODS AND RESULTS: Seventy-seven HCM patients were followed for 20 
      years. Creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), LDH-1, troponin 
      T and myosin light chain-1 (MLC-1) were measured. Abnormal CK-MB elevation was 
      observed in 64% of HCM patients. LDH-1 was not significantly different compared 
      with the control subjects. Troponin T elevation was observed in 3 HCM patients 
      and MLC-1 elevation was not observed. According to median CK-MB, HCM patients 
      were divided into 2 groups: group H (CK-MB >/=2.5%, n=33) and group L (CK-MB <2.5%, 
      n=44). During the follow-up period in group H, LV end-diastolic dimension 
      increased (P<0.0001), fractional shortening decreased (P<0.0004), and left atrial 
      dimension increased (P<0.0001). The markers reflecting LV hypertrophy were 
      significantly decreased. In group L, LV end-diastolic dimension increased 
      (P<0.02) and left atrial dimension increased (P<0.0001). HF was observed in 18 
      patients in group H and in 4 in group L. There were 14 HF deaths in group H and 2 
      in group L, and 3 sudden cardiac deaths in group H. CONCLUSIONS: Persistent 
      elevation of cardiac enzymes in HCM patients indicates ongoing myocardial injury, 
      ultimately resulting in death by HF.
FAU - Hamada, Mareomi
AU  - Hamada M
AD  - Division of Cardiology, Uwajima City Hospital.
FAU - Shigematsu, Yuji
AU  - Shigematsu Y
FAU - Ohtani, Takashi
AU  - Ohtani T
FAU - Ikeda, Shuntaro
AU  - Ikeda S
LA  - eng
PT  - Journal Article
DEP - 20151109
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Isoenzymes)
RN  - 0 (Muscle Proteins)
RN  - 0 (Troponin T)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.1.1.27.- (lactate dehydrogenase 1)
RN  - EC 2.7.11.18 (Myosin-Light-Chain Kinase)
SB  - IM
CIN - Circ J. 2016;80(1):67-8. PMID: 26632532
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiomegaly/blood/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Failure/blood/pathology
MH  - Humans
MH  - Isoenzymes/blood
MH  - L-Lactate Dehydrogenase/*blood
MH  - Male
MH  - Middle Aged
MH  - Muscle Proteins/*blood
MH  - Myosin-Light-Chain Kinase/*blood
MH  - Prospective Studies
MH  - Troponin T/*blood
EDAT- 2015/11/10 06:00
MHDA- 2016/10/11 06:00
CRDT- 2015/11/10 06:00
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/10/11 06:00 [medline]
AID - 10.1253/circj.CJ-15-0872 [doi]
PST - ppublish
SO  - Circ J. 2016;80(1):218-26. doi: 10.1253/circj.CJ-15-0872. Epub 2015 Nov 9.