PMID- 26549629 OWN - NLM STAT- MEDLINE DCOM- 20160927 LR - 20181113 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 169 IP - 1-3 DP - 2015 Dec TI - Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. PG - 340-345 LID - S0920-9964(15)30037-2 [pii] LID - 10.1016/j.schres.2015.10.037 [doi] AB - BACKGROUND: The N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. METHOD: This cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome (n=29), a psychotic disorder (n=22), or healthy controls (n=17). RESULTS: Linear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. CONCLUSIONS: Longitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Gonzalez-Heydrich, Joseph AU - Gonzalez-Heydrich J AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. Electronic address: Joseph.Gonzalez-Heydrich@childrens.harvard.edu. FAU - Bosquet Enlow, Michelle AU - Bosquet Enlow M AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. FAU - D'Angelo, Eugene AU - D'Angelo E AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA; Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA. FAU - Gumlak, Sarah AU - Gumlak S AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Kim, April AU - Kim A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Woodberry, Kristen A AU - Woodberry KA AD - Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA. FAU - Rober, Ashley AU - Rober A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Tembulkar, Sahil AU - Tembulkar S AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Graber, Kelsey AU - Graber K AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - O'Donnell, Kyle AU - O'Donnell K AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Hamoda, Hesham M AU - Hamoda HM AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. FAU - Kimball, Kara AU - Kimball K AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Rotenberg, Alexander AU - Rotenberg A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA. FAU - Oberman, Lindsay M AU - Oberman LM AD - E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, Neuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USA. FAU - Pascual-Leone, Alvaro AU - Pascual-Leone A AD - Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA; Beth Israel Deaconess Medical Center, Division of Cognitive Neurology and Berenson-Allen Center, 330 Brookline Avenue, Boston, MA 02115, USA. FAU - Keshavan, Matcheri S AU - Keshavan MS AD - Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA. FAU - Duffy, Frank H AU - Duffy FH AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA. LA - eng GR - K23 MH102358/MH/NIMH NIH HHS/United States GR - R01 MH100186/MH/NIMH NIH HHS/United States GR - 1R01MH100186/MH/NIMH NIH HHS/United States GR - U01 MH08198-06A1/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20151106 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Acoustic Stimulation MH - Adolescent MH - Analysis of Variance MH - Child MH - Child, Preschool MH - Electroencephalography MH - Evoked Potentials, Auditory/*physiology MH - Female MH - Humans MH - Linear Models MH - Male MH - Psychiatric Status Rating Scales MH - Schizophrenia/*physiopathology PMC - PMC4821005 MID - NIHMS772312 OTO - NOTNLM OT - Clinical high risk OT - Early onset OT - N100 OT - Psychosis OT - Schizophrenia OT - Superior temporal cortex COIS- Conflict of Interest In the past 3 years, Joseph Gonzalez-Heydrich has received grant support from the Tommy Fuss Fund, the Al Rashed Family, and Glaxo-SmithKline. In previous years, he served as a consultant to Abbott Laboratories, Pfizer Inc., Johnson & Johnson (Janssen, McNeil Consumer Health), Novartis, Parke-Davis, Glaxo-SmithKline, AstraZeneca, and Seaside Therapeutics; was a speaker for Abbott Laboratories, Pfizer Inc., Novartis, Bristol-Meyers Squibb; and received grant support from Abbott Laboratories, Pfizer Inc., Johnson & Johnson (Janssen, McNeil Consumer Health), and Akzo-Nobel/Organon. He is a founder, equity holder, and consultant to Neuro'motion Labs and is an inventor on a patent pending for technologies to enhance the development of emotional regulation. Alvaro Pascual-Leone serves on the scientific advisory boards for Nexstim, Neuronix, Starlab Neuroscience, Neuroelectrics, and Neosync and is listed as an inventor on several issued and pending patents on the real-time integration of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) and magnetic resonance imaging (MRI). Alexander Rotenberg has served as an advisor for NexstimInc., Sage Therapeutics Inc., and NeuroRex Inc. and has joint grants with Brainsway Inc. and Vivonics Inc. He is a founder, equity holder, and consultant to Neuro'motion Labs and is an inventor on a patent pending for technologies to enhance the development of emotional regulation. EDAT- 2015/11/10 06:00 MHDA- 2016/09/28 06:00 PMCR- 2016/12/01 CRDT- 2015/11/10 06:00 PHST- 2015/07/16 00:00 [received] PHST- 2015/10/22 00:00 [revised] PHST- 2015/10/26 00:00 [accepted] PHST- 2015/11/10 06:00 [entrez] PHST- 2015/11/10 06:00 [pubmed] PHST- 2016/09/28 06:00 [medline] PHST- 2016/12/01 00:00 [pmc-release] AID - S0920-9964(15)30037-2 [pii] AID - 10.1016/j.schres.2015.10.037 [doi] PST - ppublish SO - Schizophr Res. 2015 Dec;169(1-3):340-345. doi: 10.1016/j.schres.2015.10.037. Epub 2015 Nov 6.