PMID- 26549987
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20220410
IS  - 1475-2867 (Print)
IS  - 1475-2867 (Electronic)
IS  - 1475-2867 (Linking)
VI  - 15
DP  - 2015
TI  - Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity.
PG  - 106
LID - 10.1186/s12935-015-0260-7 [doi]
LID - 106
AB  - Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the 
      first step in the synthesis of prostanoids, is associated with inflammatory 
      diseases and carcinogenesis, which is suspected to promote angiogenesis and 
      tissue invasion of tumors and resistance to apoptosis. Meanwhile, COX-2 
      contributes to immune evasion and resistance to cancer immunotherapy, which plays 
      a crucial role in the innate and adaptive immune response. The activity of 
      COX-2-PGE2-EP signal pathway can suppress Dendritic cells (DCs), natural killer 
      (NK), T cells, type-1 immunity excluding type-2 immunity which promote tumor 
      immune evasion. COX-2 and the prostaglandin cascade play important roles in the 
      "inflammogenesis of cancer". In addition, COX-inhibitors can inhibit tumor immune 
      evasion. Therefore, we can exert the COX-inhibitors to facilitate the patients to 
      benefit from addition of COX-inhibitors to standard cytotoxic therapy.
FAU - Liu, Bing
AU  - Liu B
AD  - Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang 
      University, #88 Jie Fang Road, 310009 Hangzhou, Zhejiang People's Republic of 
      China.
FAU - Qu, Liyan
AU  - Qu L
AD  - Clinical Laboratory Centre, 2nd Affiliated Hospital, School of Medicine, Zhejiang 
      University, #88 Jie Fang Road, 310009 Hangzhou, Zhejiang People's Republic of 
      China ; Clinical Laboratory Centre, Binjiang Hospital of Hangzhou, Hangzhou, 
      Zhejiang People's Republic of China.
FAU - Yan, Shigui
AU  - Yan S
AD  - Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang 
      University, #88 Jie Fang Road, 310009 Hangzhou, Zhejiang People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151105
PL  - England
TA  - Cancer Cell Int
JT  - Cancer cell international
JID - 101139795
PMC - PMC4635545
OTO - NOTNLM
OT  - Adaptive immunity
OT  - COX-2
OT  - COX-inhibitors
OT  - EP
OT  - Innate immunity
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2015/11/05
CRDT- 2015/11/10 06:00
PHST- 2015/07/18 00:00 [received]
PHST- 2015/10/28 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2015/11/05 00:00 [pmc-release]
AID - 260 [pii]
AID - 10.1186/s12935-015-0260-7 [doi]
PST - epublish
SO  - Cancer Cell Int. 2015 Nov 5;15:106. doi: 10.1186/s12935-015-0260-7. eCollection 
      2015.