PMID- 26549997
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20200930
IS  - 1507-1367 (Print)
IS  - 2083-4640 (Electronic)
IS  - 1507-1367 (Linking)
VI  - 20
IP  - 5
DP  - 2015 Sep-Oct
TI  - Safety of adjuvant intensity-modulated postoperative radiation therapy in 
      endometrial cancer: Clinical data and dosimetric parameters according to the 
      International Commission on Radiation Units (ICRU) 83 report.
PG  - 385-92
LID - 10.1016/j.rpor.2015.06.002 [doi]
AB  - AIM: To report a single-institution experience using postoperative pelvic 
      Intensity Modulation Radiation Therapy (IMRT) using tomotherapy accelerators (TA) 
      in postoperative endometrial cancer (EC) regarding ICRU 83 recommendations. 
      BACKGROUND: IMRT in gynecological malignancies provides excellent dosimetric 
      data, lower rates of adverse events and clinical data similar to historical 
      series. MATERIAL AND METHODS: Seventy-six patients with EC were postoperatively 
      treated with adjuvant IMRT using TA. The IMRT dose was 45 Gy for patients without 
      positive lymph nodes and Type I histology and 50.4 Gy for patients with positive 
      lymph nodes and/or type II histology. RESULTS: With a median follow-up of 29 
      months, the 12- and 24-month Overall Survival (OS) and Disease-Free Survival 
      (DFS) were 96%, 93%, 87%, and 74%, respectively. Age of less than 60 years was 
      associated with better OS (HR: 8.9; CI: 1.1-68) and DFS (HR: 3.5; CI: 1.2-10.2). 
      Patients with Type II and Type I Grade III histology had a worse OS (HR: 3.3; CI: 
      1.1-11). Five women (6.6%) presented in-field local vaginal recurrence, 2 (2.6%) 
      presented non-in-field vaginal recurrence, 4 (5.2%) presented pelvic node and 
      distant recurrence and 11 (14.4%) presented only distant metastases. One patient 
      stopped radiation treatment due to Grade III acute diarrhea. No Grade III late 
      toxicity was observed. Planning Target Volume (PTV) coverage showed mean D2, D50, 
      D95, and D98 of 51.64-46.23 Gy, 49.49-44.97 Gy, 48.62-43.96 Gy, and 
      48.47-43.58 Gy for patients who received 45 and 50.4 Gy, respectively. 
      CONCLUSIONS: IMRT with TA in postoperative EC shows excellent conformity and 
      homogeneity of PTV dose. Without Grade III late toxicity, data from this cohort 
      demonstrated the utility of IMRT.
FAU - Cordoba, Abel
AU  - Cordoba A
AD  - Department of Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Nickers, Philippe
AU  - Nickers P
AD  - Department of Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Tresch, Emmanuelle
AU  - Tresch E
AD  - Department of Statistic, Centre de Lutte Contre le Cancer Oscar Lambret, 3 rue 
      Combemale, 59020 Lille cedex, France.
FAU - Castelain, Bernard
AU  - Castelain B
AD  - Department of Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Leblanc, Eric
AU  - Leblanc E
AD  - Department of Surgery, Centre de Lutte Contre le Cancer Oscar Lambret, 3 rue 
      Combemale, 59020 Lille cedex, France.
FAU - Narducci, Fabrice
AU  - Narducci F
AD  - Department of Surgery, Centre de Lutte Contre le Cancer Oscar Lambret, 3 rue 
      Combemale, 59020 Lille cedex, France.
FAU - Le Tinier, Florence
AU  - Le Tinier F
AD  - Department of Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Lesoin, Anne
AU  - Lesoin A
AD  - Department of Clinical Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Lacornerie, Thomas
AU  - Lacornerie T
AD  - Department of Radiation Physics, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
FAU - Lartigau, Eric
AU  - Lartigau E
AD  - Department of Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, 
      3 rue Combemale, 59020 Lille cedex, France.
LA  - eng
PT  - Journal Article
DEP - 20150703
PL  - Poland
TA  - Rep Pract Oncol Radiother
JT  - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer 
      Center in Poznan and Polish Society of Radiation Oncology
JID - 100885761
PMC - PMC4597088
OTO - NOTNLM
OT  - Endometrial cancer
OT  - ICRU83
OT  - IMRT
OT  - Tomotherapy
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2016/09/01
CRDT- 2015/11/10 06:00
PHST- 2015/01/12 00:00 [received]
PHST- 2015/04/23 00:00 [revised]
PHST- 2015/06/11 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - S1507-1367(15)00087-5 [pii]
AID - 10.1016/j.rpor.2015.06.002 [doi]
PST - ppublish
SO  - Rep Pract Oncol Radiother. 2015 Sep-Oct;20(5):385-92. doi: 
      10.1016/j.rpor.2015.06.002. Epub 2015 Jul 3.