PMID- 26550151
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 8
DP  - 2015
TI  - Study on encapsulation of chlorine dioxide in gelatin microsphere for reducing 
      release rate.
PG  - 12404-10
AB  - OBJECTIVE: This study aims to explore the effects of encapsulation of chlorine 
      dioxide in a hydrophilic biodegradable polymer gelatin to reduce its release 
      rate. METHODS: An emulsification-coacervation method was adopted. The 
      characterizations of chlorine dioxide-gelatin microspheres were described. Using 
      UV-vis spectrophotometer the lambdamax of chlorine dioxide was observed at 358 nm. The 
      particle size and distribution of chlorine oxide-gelatin microspheres was 
      measured by a dynamic light scattering (DLS) method, the diameter was (1400~1900) 
      nm. The entrapment of chlorine dioxide-gelatin microspheres was confirmed by IR. 
      The surface morphology, size, and shape of chlorine dioxide-gelatin microspheres 
      were analyzed using Scanning electron microscope (SEM). RESULTS: It showed that 
      the encapsulated microspheres size was around 2000 nm with uniform distribution. 
      The percentage entrapment of chlorine dioxide in the encapsulated samples was 
      about 80~85%. A slow release study of chlorine dioxide from the encapsulated 
      biopolymer (gelatin) in air was also carried out, which showed continuous release 
      up to ten days. CONCLUSIONS: It can be concluded that it is possible to make a 
      slow release formulation of ClO2 by entrapped in a hydrophilic biodegradable 
      polymer gelatin. ClO2-gelatin microspheres can stable release low concentration 
      ClO2 gas over an extended period.
FAU - Ci, Ying
AU  - Ci Y
AD  - Chinese Academy of Inspection and Quarantine Beijing 100176, China.
FAU - Wang, Lin
AU  - Wang L
AD  - Chinese Academy of Inspection and Quarantine Beijing 100176, China.
FAU - Guo, Yanchuan
AU  - Guo Y
AD  - Technical Institute of Physics and Chemistry, CAS Beijing 100190, China.
FAU - Sun, Ruixue
AU  - Sun R
AD  - Nan Yang Normal University Nanyang 473061, Henan, China.
FAU - Wang, Xijie
AU  - Wang X
AD  - Technical Institute of Physics and Chemistry, CAS Beijing 100190, China.
FAU - Li, Jinyou
AU  - Li J
AD  - Chinese Academy of Inspection and Quarantine Beijing 100176, China.
LA  - eng
PT  - Journal Article
DEP - 20150815
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4612836
OTO - NOTNLM
OT  - Chlorine dioxide
OT  - encapsulation
OT  - gelatin
OT  - microsphere
OT  - release rate
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2015/08/15
CRDT- 2015/11/10 06:00
PHST- 2015/03/18 00:00 [received]
PHST- 2015/07/01 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2015/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Aug 15;8(8):12404-10. eCollection 2015.