PMID- 26550303
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20220408
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 8
DP  - 2015
TI  - Effect of low dose rocuronium in preventing ventilation leak for flexible 
      laryngeal mask airway during radical mastectomy.
PG  - 13616-21
AB  - The flexible laryngeal mask airway (FLMA) is becoming more and more popular in 
      general anesthesia during surgery of head, neck and upper chest. But very limited 
      information has been published about whether muscle relaxant was necessary or not 
      for anesthesia with FLMA. To investigate whether low-dose muscle relaxant is 
      necessary in preventing ventilation leak of FLMA in radical mastectomy, 
      forty-eight female patients undergoing radical mastectomy were enrolled in the 
      study. They were randomly divided into low-dose muscle relaxant (LD-MR) group and 
      non-muscle relaxant (non-MR) group. All the included patients received total 
      intravenous anesthesia (with propofol, fentanyl and remifentanil) and controlled 
      mechanical ventilation with FLMA during the surgery. Patients in LD-MR group 
      received 0.4 mg/kg rocuronium during anesthesia induction, while patients in 
      non-MR group received equivalent volumes of physiological saline. Insertion time 
      was shorter in LD-MR group than that in non-MR group (P < 0.05). Peak airway 
      pressures and ventilation leak volumes at 10, 20 and 30 minutes were lower in 
      LD-MR group than those in non-MR group (P < 0.05). No difference was found 
      between LD-MR and non-MR group in terms of emergence time, FLMA extraction time, 
      and maximum tidal volumes before FLMA extraction. The results show that low-dose 
      rocuronium could reduce the ventilation leak for mechanical ventilation with FLMA 
      during radical mastectomy without prolonging the emergence time.
FAU - Gong, Ya-Hong
AU  - Gong YH
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College 1 Shuai Fuyuan, 
      Wangfujing Street, Dongcheng District, Beijing 100730, China.
FAU - Yi, Jie
AU  - Yi J
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College 1 Shuai Fuyuan, 
      Wangfujing Street, Dongcheng District, Beijing 100730, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Graduate Division, Hebei North University Zhangjiakou City 075000, Hebei 
      Province, China.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College 1 Shuai Fuyuan, 
      Wangfujing Street, Dongcheng District, Beijing 100730, China.
LA  - eng
PT  - Journal Article
DEP - 20150815
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4612988
OTO - NOTNLM
OT  - Rocuronium
OT  - flexible laryngeal mask airway
OT  - radical mastectomy
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2015/08/15
CRDT- 2015/11/10 06:00
PHST- 2015/05/24 00:00 [received]
PHST- 2015/07/12 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2015/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Aug 15;8(8):13616-21. eCollection 2015.