PMID- 26550367
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 8
DP  - 2015
TI  - The influence of hypoglycemic drugs on exercise-mediated hypoglycemic effects in 
      elderly type 2 diabetic patients.
PG  - 14054-9
AB  - BACKGROUND: To evaluate the impact of different hypoglycemic drugs on 
      exercise-mediated blood glucose (BG) reduction. METHODS: One-hundred and five 
      retirees who were diagnosed with type 2 diabetes mellitus (T2DM) within a 
      two-year period were included in this study. The participants were instructed to 
      walk for 20 to 30 minutes at a moderate-speed (4.0 to 4.5 km/h) after breakfast. 
      Blood pressure and fingertip BG were measured before and after walking. RESULTS: 
      The rate of BG reduction was significantly higher in all exercise groups when 
      compared to that of non-exercised patients. Among all groups, BG declined the 
      most in the un-medicated group, while the lowest BG reduction was observed in the 
      acarbose group. Surprisingly, the BG reduction in acarbose group was 
      significantly lower when compared with non-acarbose groups (P<0.0001). 
      Interestingly, after further correcting for sex, age, BMI, diabetes history, 
      walking time, walking speed and walking distance, only age was found to be an 
      influencing factor (t=-3.304, P=0.001). Pearson correlation of age and BG 
      reduction showed that correlation coefficient of age was only 0.183 and revealed 
      no statistical significance. CONCLUSIONS: Walking at a moderate speed for 20 to30 
      minutes after breakfast provided a beneficial BG reduction effect in elderly T2DM 
      patients. Among the medicated groups, the smallest BG reduction rate was observed 
      in patients taking acarbose. We suggest that acarbose might influence 
      hypoglycemic effects of exercise. The results of this study will be helpful for 
      determining the best clinical usage of hypoglycemic medications in elderly T2DM 
      patients.
FAU - Xu, Qin
AU  - Xu Q
AD  - The Rest Center of TaiHu Sanatorium of Jiangsu Province Yuan Tou Zhu, Wuxi 
      214086, China.
FAU - Wang, Fengdi
AU  - Wang F
AD  - The Rest Center of TaiHu Sanatorium of Jiangsu Province Yuan Tou Zhu, Wuxi 
      214086, China.
FAU - Wu, Yuemei
AU  - Wu Y
AD  - The Rest Center of TaiHu Sanatorium of Jiangsu Province Yuan Tou Zhu, Wuxi 
      214086, China.
FAU - Li, Feng
AU  - Li F
AD  - The Rest Center of TaiHu Sanatorium of Jiangsu Province Yuan Tou Zhu, Wuxi 
      214086, China.
LA  - eng
PT  - Journal Article
DEP - 20150815
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4613052
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - acarbose
OT  - exercise
OT  - hypoglycemia
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2015/08/15
CRDT- 2015/11/10 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/08/06 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2015/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Aug 15;8(8):14054-9. eCollection 2015.