PMID- 26550371
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151109
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 8
DP  - 2015
TI  - Distribution of monocyte chemoattractant protein-1 (MCP-1 A-2518G) and chemokine 
      receptor (CCR2-V64Iota) gene variants in hyperbilirubinemic newborns.
PG  - 14075-9
AB  - Hyperbilirubinemia is one of the most crucial syndromes, which is characterized 
      by high levels of bilirubin, especially when it occurs in newborns. Bilirubin has 
      cytoprotective properties with an antioxidant function and plays several major 
      roles in the inflammation process with its members such as chemokines. The 
      monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine 
      family and it has been associated with the inflammatory process. There are no 
      data on the chemokine and its receptor genotypes in hyperbilirubinemic newborns 
      to show their distribution. The aim of this study is to investigate the genotypic 
      relationship of MCP-1 and its receptor CCR2-V64Iota with hyperbilirubinemia in 
      Turkish newborns. A total of 85 newborns were included in the study: 20 infants 
      with hyperbilirubinemia (hyperbilirubinemic group) and 65 infants without 
      hyperbilirubinemia (non-hyperbilirubinemic group). Genotyping of MCP-1 A-2518G 
      and CCR2-V64Iota gene polymorphisms were detected by PCR-RFLP, respectively. MCP-1 
      GG genotype in patients was higher than the controls and this genotype had 2.69 
      times higher risk for hyperbilirubinemic neonates (P: 0.20). The frequency of 
      MCP-1 A-2518G G+ genotype in patients was higher than the controls (55.0% and 
      38.5%, respectively). The results of our preliminary study suggest that MCP-1 G+ 
      genotype has the ability to increase the hyperbilirubinemia risk of newborns. 
      These results should be focused on to research on a larger scale to confirm the 
      findings.
FAU - Narter, Fatma
AU  - Narter F
AD  - Department of Pediatrics, Division of Neonatology, Kartal Dr. Lutfi Kirdar 
      Education and Training Hospital Kartal, Istanbul, Turkey.
FAU - Bireller, Elif Sinem
AU  - Bireller ES
AD  - Department of Molecular Medicine, Istanbul University, Institute of Experimental 
      Medical Research Capa, Istanbul, Turkey.
FAU - Engin, Can
AU  - Engin C
AD  - Department of Molecular Medicine, Istanbul University, Institute of Experimental 
      Medical Research Capa, Istanbul, Turkey.
FAU - Catmakas, Tolga
AU  - Catmakas T
AD  - Department of Molecular Medicine, Istanbul University, Institute of Experimental 
      Medical Research Capa, Istanbul, Turkey.
FAU - Narter, Fehmi
AU  - Narter F
AD  - Department of Urology, Kartal Dr. Lutfi Kirdar Education and Training Hospital 
      Kartal, Istanbul, Turkey.
FAU - Ergen, Arzu
AU  - Ergen A
AD  - Department of Molecular Medicine, Istanbul University, Institute of Experimental 
      Medical Research Capa, Istanbul, Turkey.
FAU - Cakmakoglu, Bedia
AU  - Cakmakoglu B
AD  - Department of Molecular Medicine, Istanbul University, Institute of Experimental 
      Medical Research Capa, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150815
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4613056
OTO - NOTNLM
OT  - CCR2
OT  - MCP-1 and newborn
OT  - hyperbilirubinemia
EDAT- 2015/11/10 06:00
MHDA- 2015/11/10 06:01
PMCR- 2015/08/15
CRDT- 2015/11/10 06:00
PHST- 2015/04/22 00:00 [received]
PHST- 2015/08/03 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2015/11/10 06:01 [medline]
PHST- 2015/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Aug 15;8(8):14075-9. eCollection 2015.