PMID- 26550972
OWN - NLM
STAT- MEDLINE
DCOM- 20170508
LR  - 20190221
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 25
IP  - 5
DP  - 2016 May
TI  - Effect of Axial Length on Macular Ganglion Cell Complex Thickness and on Early 
      Glaucoma Diagnosis by Spectral-Domain Optical Coherence Tomography.
PG  - e481-90
LID - 10.1097/IJG.0000000000000330 [doi]
AB  - PURPOSE: To investigate the effects of the axial length (AL)-related ocular 
      magnification on the thickness of the macular ganglion cell complex (mGCC), and 
      the diagnostic accuracy of the built-in normative database of the spectral-domain 
      optical coherence tomographic (SD-OCT) instrument for early glaucoma detection. 
      METHODS: This retrospective study included 41 eyes with early primary open-angle 
      glaucoma and 36 normal eyes. The mGCC thickness within a 20-degree circle, 
      equivalent to a 6 mm diameter in the Gullstrand model eye, was measured in the 
      SD-OCT images. The magnification effect was corrected using Bennett formula, and 
      the mGCC thickness within the actual 6 mm diameter circle was determined. 
      RESULTS: In normal eyes, the inferior corrected mGCC was significantly correlated 
      with the AL (beta=-0.40, P=0.028), but correction for the magnification reduced the 
      correlation. In 38 nonhighly myopic eyes, the sensitivity and specificity of the 
      SD-OCT's significance maps for distinguishing early glaucoma were 95.0% and 94.4% 
      when using either the uncorrected or the corrected mGCC. In 39 highly myopic 
      eyes, the diagnostic accuracy was lower when using the uncorrected mGCC thickness 
      (sensitivity was 95.2% and specificity was 44.4%), and was not improved when 
      using the corrected mGCC (81.0% and 61.1%, respectively). CONCLUSIONS: The 
      inferior mGCC was thinner in eyes with longer AL. The accuracy of the diagnosis 
      with the SD-OCT built-in normative database for early glaucoma was not improved 
      significantly by the correction of the AL-associated magnification in highly 
      myopic eyes. Evaluation of highly myopic eyes with the nonhighly myopic normative 
      database can lead to misdiagnosis.
FAU - Nakanishi, Hideo
AU  - Nakanishi H
AD  - *Department of Ophthalmology and Visual Sciences, Kyoto University Graduate 
      School of Medicine, Sakyo-ku, Kyoto daggerDepartment of Ophthalmology, Saitama Medical 
      University, Moroyama, Saitama, Japan.
FAU - Akagi, Tadamichi
AU  - Akagi T
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Kimura, Yugo
AU  - Kimura Y
FAU - Suda, Kenji
AU  - Suda K
FAU - Hasegawa, Tomoko
AU  - Hasegawa T
FAU - Yamada, Hiroshi
AU  - Yamada H
FAU - Yoshikawa, Munemitsu
AU  - Yoshikawa M
FAU - Morooka, Satoshi
AU  - Morooka S
FAU - Ikeda, Hanako Ohashi
AU  - Ikeda HO
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Axial Length, Eye/*pathology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Early Diagnosis
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/methods
EDAT- 2015/11/10 06:00
MHDA- 2017/05/10 06:00
CRDT- 2015/11/10 06:00
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
AID - 10.1097/IJG.0000000000000330 [doi]
PST - ppublish
SO  - J Glaucoma. 2016 May;25(5):e481-90. doi: 10.1097/IJG.0000000000000330.