PMID- 26550975
OWN - NLM
STAT- MEDLINE
DCOM- 20160831
LR  - 20190221
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 25
IP  - 4
DP  - 2016 Apr
TI  - Segmental Analysis of Macular Layers in Patients With Unilateral Primary 
      Open-Angle Glaucoma.
PG  - e401-7
LID - 10.1097/IJG.0000000000000336 [doi]
AB  - PURPOSE: To measure the thicknesses of the inner layers of the macula in both 
      eyes of patients with unilateral primary open-angle glaucoma (POAG) and compare 
      them with normal control eyes. METHODS: This prospective, cross-sectional pilot 
      study enrolled patients with unilateral POAG, who had visual field defect in only 
      1 eye, and controls with a normal eye examination. Horizontal and vertical B-scan 
      images centered on the fovea were obtained using spectral domain optical 
      coherence. Semiautomatic delineation and segmentation of the inner layers of the 
      retina were performed to evaluate macular retinal nerve fiber layer (mRNFL), 
      ganglion cell complex (GCC) and ganglion cell-inner plexiform layer (GC-IPL) 
      thicknesses. Mean, superior, inferior, nasal, and temporal inner macular layer 
      thicknesses were compared between affected eyes, fellow eyes without visual field 
      defect, and control eyes. RESULTS: Nineteen patients with unilateral POAG and 14 
      normal control eyes were enrolled. In the affected POAG eyes, thinning of the 
      mRNFL, GCC, and GC-IPL layers on horizontal and vertical scans were significant 
      when compared with controls (P<0.05), particularly on vertical scans (P<0.001). 
      The mean regional macular GCC and GC-IPL were most severely thinned in the 
      inferior and temporal perifoveal regions. The unaffected eye of patients with 
      unilateral POAG showed significant thinning of the mRNFL only in the vertical 
      scan when compared with normal controls (P<0.05). CONCLUSIONS: Spectral domain 
      optical coherence tomography detected significant thinning of the mRNFL, GCC, and 
      GC-IPL in the affected eyes of patients with unilateral POAG. Fellow eyes showed 
      early structural changes only in the vertical mRNFL scans when compared with 
      normal controls.
FAU - Zangalli, Camila S
AU  - Zangalli CS
AD  - *Glaucoma Research Center daggerDiagnostic Center double daggerNeuro-ophthalmology Service, Wills 
      Eye Hospital, Philadelphia, PA.
FAU - Ahmed, Osama M
AU  - Ahmed OM
FAU - Waisbourd, Michael
AU  - Waisbourd M
FAU - H Ali, Mohsin
AU  - H Ali M
FAU - Cvintal, Victor
AU  - Cvintal V
FAU - Affel, Elizabeth
AU  - Affel E
FAU - Gupta, Lalita
AU  - Gupta L
FAU - Katz, L Jay
AU  - Katz LJ
FAU - C Sergott, Robert
AU  - C Sergott R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/methods
EDAT- 2015/11/10 06:00
MHDA- 2016/09/01 06:00
CRDT- 2015/11/10 06:00
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/09/01 06:00 [medline]
AID - 10.1097/IJG.0000000000000336 [doi]
PST - ppublish
SO  - J Glaucoma. 2016 Apr;25(4):e401-7. doi: 10.1097/IJG.0000000000000336.