PMID- 26551699
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20161230
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 43
IP  - 4
DP  - 2015 Aug
TI  - NRF2 and microRNAs: new but awaited relations.
PG  - 595-601
LID - 10.1042/BST20140317 [doi]
AB  - The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a 
      key player in the cellular antioxidant response and it also controls various 
      other functions in a cell-type specific manner. Due to these key functions, a 
      tight control of NRF2 expression and activity is essential. This regulation is 
      exerted at multiple levels, including transcriptional regulation and proteasomal 
      degradation. Recent studies revealed important roles of miRNAs (miRs) in the 
      control of NRF2 activity through direct targeting of the NRF2 mRNA and of mRNAs 
      encoding proteins that control the level and activity of NRF2. In addition, NRF2 
      itself has been identified as a regulator of miRs, which exert some of the 
      functions of NRF2 in metabolic regulation and also novel functions in the 
      regulation of cell adhesion. Here, we summarize the roles and mechanisms of 
      action of miRs in the regulation of NRF2 activity and as downstream effectors of 
      this transcription factor.
CI  - (c) 2015 Authors; published by Portland Press Limited.
FAU - Kurinna, Svitlana
AU  - Kurinna S
AD  - Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 
      Zurich, Switzerland svitlana.kurinna@biol.ethz.ch sabine.werner@biol.ethz.ch.
FAU - Werner, Sabine
AU  - Werner S
AD  - Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 
      Zurich, Switzerland svitlana.kurinna@biol.ethz.ch sabine.werner@biol.ethz.ch.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150803
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (MicroRNAs)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Gene Expression Regulation
MH  - Humans
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - MicroRNAs/*genetics
MH  - NF-E2-Related Factor 2/*genetics/*metabolism
MH  - Proteasome Endopeptidase Complex/metabolism
OTO - NOTNLM
OT  - cell-cell adhesion
OT  - metabolism
OT  - micro ribonucleic acid (miRNA)
OT  - nuclear factor erythroid 2-related factor 2 (NRF2)
OT  - transcriptional regulation
EDAT- 2015/11/10 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/11/10 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - BST20140317 [pii]
AID - 10.1042/BST20140317 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2015 Aug;43(4):595-601. doi: 10.1042/BST20140317. Epub 2015 
      Aug 3.