PMID- 26552011
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20151228
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 610
DP  - 2016 Jan 1
TI  - Rolipram-induced improvement of cognitive function correlates with changes in 
      hippocampal CREB phosphorylation, BDNF and Arc protein levels.
PG  - 171-6
LID - S0304-3940(15)30149-X [pii]
LID - 10.1016/j.neulet.2015.09.023 [doi]
AB  - Diabetics suffer from a higher risk of cognitive decline. cAMP response 
      element-binding protein (CREB) is a transcription factor associated with memory 
      and synaptic plasticity. Here, we investigated the molecular changes in the 
      hippocampus correlated with diabetes associated cognitive decline (DACD) from a 
      CREB-centered perspective in a rat model of type 2 diabetes. Furthermore, we 
      tested the therapeutic effect of rolipram on DACD. High-fat diet and low-dose 
      streptozocin were adopted to induce diabetes in SD rats. Results show that 
      supplementation with rolipram for 23 days (0.5mg/kg, once a day) improved the 
      performance of diabetic rats in Morris water navigation task with increased level 
      of CREB, brain-derived neurotrophic factor (BDNF), and Arc protein in the 
      hippocampus. Rolipram, acting as an inhibitor of PDE4, was found to repair the 
      imbalance in the CREB/BDNF/Arc pathway. This study may provide important insights 
      into the mechanisms underlying DACD and provide new therapeutic targets for 
      clinical treatment.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhong, Yuan
AU  - Zhong Y
AD  - Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's 
      Hospital, 600 Yi Shan Road, Shanghai 200233, China.
FAU - Zhu, Yitong
AU  - Zhu Y
AD  - Department of Boxi medical center, The First Affiliated Hospital of Soochow 
      University, No. 188 Shizi St, Suzhou, Jiangsu 215006, China.
FAU - He, Ting
AU  - He T
AD  - Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's 
      Hospital, 600 Yi Shan Road, Shanghai 200233, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's 
      Hospital, 600 Yi Shan Road, Shanghai 200233, China.
FAU - Yan, Hong
AU  - Yan H
AD  - Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's 
      Hospital, 600 Yi Shan Road, Shanghai 200233, China.
FAU - Miao, Ya
AU  - Miao Y
AD  - Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's 
      Hospital, 600 Yi Shan Road, Shanghai 200233, China. Electronic address: 
      nning-my@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151110
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Muscle Proteins)
RN  - 0 (Nol3 protein, rat)
RN  - 0 (Phosphodiesterase 4 Inhibitors)
RN  - K676NL63N7 (Rolipram)
SB  - IM
MH  - Animals
MH  - Apoptosis Regulatory Proteins/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*drug effects
MH  - Cognition Disorders/drug therapy/etiology/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Diabetes Mellitus, Experimental/complications/metabolism/psychology
MH  - Diabetes Mellitus, Type 2/complications/metabolism/psychology
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory, Short-Term/drug effects
MH  - Muscle Proteins/*metabolism
MH  - Phosphodiesterase 4 Inhibitors/*pharmacology/therapeutic use
MH  - Phosphorylation
MH  - Rats, Sprague-Dawley
MH  - Rolipram/*pharmacology/therapeutic use
MH  - Spatial Learning/drug effects
OTO - NOTNLM
OT  - Arc protein
OT  - Brain-derived neurotrophic factor
OT  - Cognition
OT  - Rolipram
OT  - cAMP response element-binding protein
EDAT- 2015/11/10 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/11/10 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/09/09 00:00 [revised]
PHST- 2015/09/21 00:00 [accepted]
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - S0304-3940(15)30149-X [pii]
AID - 10.1016/j.neulet.2015.09.023 [doi]
PST - ppublish
SO  - Neurosci Lett. 2016 Jan 1;610:171-6. doi: 10.1016/j.neulet.2015.09.023. Epub 2015 
      Nov 10.