PMID- 26552151
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20181202
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 50
IP  - 7
DP  - 2015 Jul
TI  - [UPLC-Q-TOF/MS analysis of phospholipids metabolite profiling in plasma of type 2 
      diabetes mellitus rat].
PG  - 882-6
AB  - This study reported the analysis of plasma phospholipid metabolism of the rats 
      and the pathological biomarkers between the type 2 diabetes model control group 
      (MC) and the normal control group (NC). SD rats were randomly divided into 2 
      groups: NC and MC. To investigate state of plasma metabolite profiling in normal 
      body, type 2 diabetes mellitus (T2DM) model group using UPLC-Q-TOF/MS which was 
      used as analysis tool in this research. The compounds were identified by 
      UPLC-Q-TOF/MS based on MS/MS fragment ions information, element composition in 
      MassLynx 4.1 and the Lipid Maps database. The sign of two groups of samples in 
      specific markers for screening was through a software package in R software 
      (BioMark software). The results show that the pathological markers were mainly 
      phosphatidylcholine (PC) and triglycerides (TG); the 2-acyl PC in the MC group 
      was less more obviously than that in the NC group; high carbon number and high 
      degree of unsaturation of the TG was reduced under the condition of type 2 
      diabetes. In the state of type 2 diabetes, metabolic changes occurred in rat 
      plasma phospholipids obviously, which had a close relationship with the 
      occurrence and development of T2DM.
FAU - Zeng, Ping-yan
AU  - Zeng PY
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Rui, Wen
AU  - Rui W
FAU - Wu, Xia
AU  - Wu X
FAU - Feng, Yi-fan
AU  - Feng YF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Biomarkers)
RN  - 0 (Phospholipids)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Chromatography, High Pressure Liquid
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Metabolome
MH  - Phospholipids/*blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tandem Mass Spectrometry
EDAT- 2015/11/11 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/11/11 06:00
PHST- 2015/11/11 06:00 [entrez]
PHST- 2015/11/11 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2015 Jul;50(7):882-6.