PMID- 26553010
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20190911
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 16
IP  - 13
DP  - 2015
TI  - Proline Oxidase (POX) as A Target for Cancer Therapy.
PG  - 1464-9
AB  - Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the 
      first step of proline degradation, during which ROS and/or ATP is generated. POX 
      is widely distributed in living organisms and is responsible for a number of 
      regulatory processes such as redox homeostasis, osmotic adaptation, cell 
      signaling and oxidative stress. Recent data provided evidence that POX plays an 
      important role in carcinogenesis and tumor growth. POX may induce apoptosis in 
      both intrinsic and extrinsic way. Due to ROS generation, POX may induce caspase-9 
      activity, which mediates mitochondrial apoptosis (intrinsic apoptosis pathway). 
      POX can also stimulate TRAIL (tumor necrosis factorrelated apoptosis inducing 
      ligand) and DR5 (death receptor 5) expression, resulting in cleavage of 
      procaspase-8 and thus extrinsic apoptotic pathway. However, this tumor suppressor 
      in certain environmental conditions may act as a prosurvival factor. Genotoxic, 
      inflammatory and metabolic stress may switch POX from tumor growth inhibiting to 
      tumor growth supporting factor. The potential mechanisms which may regulate 
      switching of POX mode are discussed in this review.
FAU - Kononczuk, Joanna
AU  - Kononczuk J
FAU - Czyzewska, Urszula
AU  - Czyzewska U
FAU - Moczydlowska, Joanna
AU  - Moczydlowska J
FAU - Surazynski, Arkadiusz
AU  - Surazynski A
FAU - Palka, Jerzy
AU  - Palka J
FAU - Miltyk, Wojciech
AU  - Miltyk W
AD  - Department of Pharmaceutical Analysis, Medical University in Bialystok, ul. Adama 
      Mickiewicza 2D, 15-222 Bialystok, Poland. wmiltyk@umb.edu.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Reactive Oxygen Species)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - 9DLQ4CIU6V (Proline)
RN  - EC 1.5.3.- (Proline Oxidase)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - Apoptosis/physiology
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Neoplasms/*enzymology/pathology/therapy
MH  - Oxidative Stress/physiology
MH  - Proline/*metabolism
MH  - Proline Oxidase/*metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/physiology
EDAT- 2015/11/11 06:00
MHDA- 2016/08/30 06:00
CRDT- 2015/11/11 06:00
PHST- 2014/04/15 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2015/04/23 00:00 [accepted]
PHST- 2015/11/11 06:00 [entrez]
PHST- 2015/11/11 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
AID - CDT-EPUB-71489 [pii]
AID - 10.2174/138945011613151031150637 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2015;16(13):1464-9. doi: 10.2174/138945011613151031150637.