PMID- 26553191 OWN - NLM STAT- MEDLINE DCOM- 20160509 LR - 20181202 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 15 DP - 2015 Nov 9 TI - Evaluating the impact of cannabis use on thalamic connectivity in youth at clinical high risk of psychosis. PG - 276 LID - 10.1186/s12888-015-0656-x [doi] LID - 276 AB - BACKGROUND: Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psychosis on thalamic dysconnectivity is poorly understood. We tested whether thalamic dysconnectivity is related to patterns of cannabis use in a CHR sample. METHODS: 162 CHR and 105 control participants were assessed on cannabis use severity, frequency, and age at onset of first use as part of the North American Prodrome Longitudinal Study and completed resting-state fMRI scans. Whole-brain thalamic functional connectivity maps were generated using individual subjects' anatomically defined thalamic seeds. RESULTS: Thalamic connectivity did not significantly correlate with current cannabis use severity or frequency in either CHR or controls. In CHR cannabis users, a significant correlation emerged between attenuated thalamic connectivity with left sensory/motor cortex and a younger age at onset of cannabis use. CHR who used cannabis before age 15 did not differ on thalamic connectivity as compared to CHR who used after age 15 or CHR who were cannabis naive. No group differences in thalamic connectivity emerged when comparing CHR separated by moderate/high use frequency, low-frequency or cannabis naive. CONCLUSIONS: Although a younger age at onset of cannabis use may be associated with disrupted thalamo-cortical coupling, cannabis use does not appear to be an identifying characteristic for thalamic connectivity in CHR with moderate/high use frequency compared to low-frequency users or CHR who are cannabis naive. FAU - Buchy, Lisa AU - Buchy L AD - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. labuchy@ucalgary.ca. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychology, Yale University, New Haven, CT, USA. tyrone.cannon@yale.edu. FAU - Anticevic, Alan AU - Anticevic A AD - Department of Psychiatry, Yale University, New Haven, CT, USA. alan.anticevic@yale.edu. FAU - Lyngberg, Kristina AU - Lyngberg K AD - Department of Neuroscience, Faculty of Science, University of Calgary, Alberta, Canada. kklyngbe@ucalgary.ca. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UCSD, La Jolla, CA, USA. kcadenhead@ucsd.edu. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA. cornblat@nshs.edu. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Department of Psychiatry, Yale University, New Haven, CT, USA. Thomas.mcglashan@yale.edu. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. diana_perkins@unc.edu. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, USA. larry_seidman@hms.harvard.edu. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA. mtsuang@ucsd.edu. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, USA. psyefw@emory.edu. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, CT, USA. scott.woods@yale.edu. FAU - Bearden, Carrie E AU - Bearden CE AD - Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles, CA, USA. cbearden@mednet.ucla.edu. FAU - Mathalon, Daniel H AU - Mathalon DH AD - University of California, San Francisco, San Francisco, CA, USA. Daniel.mathalon@ucsf.edu. FAU - Addington, Jean AU - Addington J AD - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. jmadding@ucalgary.ca. AD - Mathison Centre for Mental Health Research and Education, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4Z6. jmadding@ucalgary.ca. LA - eng GR - K24 MH76191/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - R01 MH60720/MH/NIMH NIH HHS/United States GR - U01MH082004/MH/NIMH NIH HHS/United States GR - UO1 MH081857-05/MH/NIMH NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - U01MH081988/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - K24 MH076191/MH/NIMH NIH HHS/United States GR - U01MH081902/MH/NIMH NIH HHS/United States GR - U01MH081984/MH/NIMH NIH HHS/United States GR - R01 MH060720/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20151109 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Adolescent MH - Age of Onset MH - Analysis of Variance MH - Brain Mapping MH - Case-Control Studies MH - Female MH - Humans MH - Longitudinal Studies MH - Magnetic Resonance Imaging MH - Male MH - Marijuana Smoking/*adverse effects MH - Motor Cortex/physiology MH - Prodromal Symptoms MH - Psychotic Disorders/*etiology/physiopathology MH - Risk Factors MH - Schizophrenia/etiology/physiopathology MH - Thalamus/*drug effects/physiology MH - Young Adult PMC - PMC4640353 EDAT- 2015/11/11 06:00 MHDA- 2016/05/10 06:00 PMCR- 2015/11/09 CRDT- 2015/11/11 06:00 PHST- 2015/07/07 00:00 [received] PHST- 2015/10/19 00:00 [accepted] PHST- 2015/11/11 06:00 [entrez] PHST- 2015/11/11 06:00 [pubmed] PHST- 2016/05/10 06:00 [medline] PHST- 2015/11/09 00:00 [pmc-release] AID - 10.1186/s12888-015-0656-x [pii] AID - 656 [pii] AID - 10.1186/s12888-015-0656-x [doi] PST - epublish SO - BMC Psychiatry. 2015 Nov 9;15:276. doi: 10.1186/s12888-015-0656-x.