PMID- 26553372
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20220331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Nov 10
TI  - Hyperhomocysteinemia predicts renal function decline: a prospective study in 
      hypertensive adults.
PG  - 16268
LID - 10.1038/srep16268 [doi]
LID - 16268
AB  - Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular 
      injury in general and diabetic populations. However, HHcy's role in hypertensive 
      patients was not studied. We investigated whether HHcy is an independent risk 
      factor for renal function decline and development of chronic kidney disease (CKD) 
      in hypertensive men and women. This was a community-based prospective cohort 
      study of 2,387 hypertensive adults without CKD at baseline, with a mean follow-up 
      of 4.4 years. Baseline and follow-up levels of plasma Hcy, folate, vitamin B12, 
      blood pressure and other pertinent covariables were obtained. CKD was defined as 
      an estimated glomerular filtration rate (eGFR) <60 ml/min/per 1.73 m(2) and an 
      eGFR decline rate >1 ml/min/per 1.73 m(2)/year. There was a graded association 
      between Hcy tertiles and eGFR decline. Subjects in the 3(rd) tertile of Hcy 
      levels had an accelerated rate of eGFR decline and an increased risk of incident 
      CKD, as compared with those in the 1st tertile, after adjusting for age, gender, 
      baseline diabetes, SBP, BMI, smoking, dyslipidemia, eGFR, folate and vitamin B12 
      levels. In conclusion, in this prospective cohort of Chinese hypertensive adults, 
      elevated baseline plasma Hcy can serve as an independent biomarker to predict 
      renal function decline and incident CKD.
FAU - Xie, Di
AU  - Xie D
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Yuan, Yan
AU  - Yuan Y
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Guo, Jiangnan
AU  - Guo J
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Yang, Shenglin
AU  - Yang S
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Xu, Xin
AU  - Xu X
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Wang, Qin
AU  - Wang Q
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Li, Youbao
AU  - Li Y
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Qin, Xianhui
AU  - Qin X
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Tang, Genfu
AU  - Tang G
AD  - School of Health Administration, Anhui Medical University, Hefei, China.
FAU - Huo, Yong
AU  - Huo Y
AD  - Department of Cardiology, Peking University First Hospital, Beijing, China.
FAU - Deng, Guangpu
AU  - Deng G
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Wu, Shengjie
AU  - Wu S
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Wang, Binyan
AU  - Wang B
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Wang, Xiaobin
AU  - Wang X
AD  - Department of Population, Family and Reproductive Health, Johns Hopkins 
      University Bloomberg School of Public Health, Baltimore, USA.
FAU - Fang, Pu
AU  - Fang P
AD  - Department of Pharmacology, Center for Metabolic Disease Research, Temple 
      University School of Medicine, Philadelphia, Pennsylvania, USA.
FAU - Wang, Hong
AU  - Wang H
AD  - Department of Pharmacology, Center for Metabolic Disease Research, Temple 
      University School of Medicine, Philadelphia, Pennsylvania, USA.
FAU - Xu, Xiping
AU  - Xu X
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Hou, Fanfan
AU  - Hou F
AD  - National Clinical Research Center of Kidney Disease, State Key Laboratory of 
      Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
LA  - eng
GR  - R01 HL077288/HL/NHLBI NIH HHS/United States
GR  - R01 HL110764/HL/NHLBI NIH HHS/United States
GR  - R01 HL117654/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151110
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - Homocysteinemia
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Cohort Studies
MH  - Demography
MH  - Female
MH  - Folic Acid/blood
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*diagnosis
MH  - Hypertension/complications/*diagnosis
MH  - Kidney/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renal Insufficiency, Chronic/*etiology
MH  - Risk Factors
MH  - Vitamin B 12/blood
PMC - PMC4639775
EDAT- 2015/11/11 06:00
MHDA- 2016/09/08 06:00
PMCR- 2015/11/10
CRDT- 2015/11/11 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/11/11 06:00 [entrez]
PHST- 2015/11/11 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
PHST- 2015/11/10 00:00 [pmc-release]
AID - srep16268 [pii]
AID - 10.1038/srep16268 [doi]
PST - epublish
SO  - Sci Rep. 2015 Nov 10;5:16268. doi: 10.1038/srep16268.