PMID- 26553517
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20220410
IS  - 1759-507X (Electronic)
IS  - 1759-5061 (Linking)
VI  - 12
IP  - 2
DP  - 2016 Feb
TI  - Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney 
      disease.
PG  - 73-81
LID - 10.1038/nrneph.2015.173 [doi]
AB  - Chronic kidney disease (CKD) is a common comorbidity in patients with type 2 
      diabetes mellitus (T2DM) and both conditions are increasing in prevalence. CKD is 
      estimated to affect  approximately 50% patients with T2DM globally, and its presence and 
      severity markedly influences disease prognosis. CKD is more common in certain 
      patient populations, including the elderly, those with youth-onset diabetes 
      mellitus, those who are obese, certain ethnic groups, and disadvantaged 
      populations. These same settings have also seen the greatest increase in the 
      prevalence of T2DM, as exemplified by the increasing prevalence of T2DM in 
      low-to- middle income countries. Patients from low-to-middle income countries are 
      often the least able to deal with the burden of T2DM and CKD and the health-care 
      facilities of these countries least able to deal with the demand for equitable 
      access to renal replacement therapies. The increasing prevalence of younger 
      individuals with T2DM, in whom an accelerated course of complications can be 
      observed, further adds to the global burden of CKD. Paradoxically, improvements 
      in cardiovascular survival in patients with T2DM have contributed to patients 
      surviving longer, allowing sufficient time to develop renal impairment. This 
      Review explores how the changing epidemiology of T2DM has influenced the 
      prevalence and incidence of associated CKD across different populations and 
      clinical settings.
FAU - Thomas, Merlin C
AU  - Thomas MC
AD  - Baker IDI Heart &Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, 
      Australia.
FAU - Cooper, Mark E
AU  - Cooper ME
AD  - Baker IDI Heart &Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, 
      Australia.
FAU - Zimmet, Paul
AU  - Zimmet P
AD  - Baker IDI Heart &Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151110
PL  - England
TA  - Nat Rev Nephrol
JT  - Nature reviews. Nephrology
JID - 101500081
SB  - IM
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Diabetic Nephropathies/complications/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Kidney Failure, Chronic/etiology
MH  - Prevalence
MH  - Renal Insufficiency, Chronic/complications/*epidemiology
MH  - Risk Factors
EDAT- 2015/11/11 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/11/11 06:00
PHST- 2015/11/11 06:00 [entrez]
PHST- 2015/11/11 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - nrneph.2015.173 [pii]
AID - 10.1038/nrneph.2015.173 [doi]
PST - ppublish
SO  - Nat Rev Nephrol. 2016 Feb;12(2):73-81. doi: 10.1038/nrneph.2015.173. Epub 2015 
      Nov 10.