PMID- 26554601
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20191210
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 408
IP  - 2
DP  - 2016 Jan
TI  - Potential of gas chromatography-atmospheric pressure chemical ionization-tandem 
      mass spectrometry for screening and quantification of hexabromocyclododecane.
PG  - 449-59
LID - 10.1007/s00216-015-9146-8 [doi]
AB  - A fast method for the screening and quantification of hexabromocyclododecane (sum 
      of all isomers) by gas chromatography using a triple quadrupole mass spectrometer 
      with atmospheric pressure chemical ionization (GC-APCI-QqQ) is proposed. This 
      novel procedure makes use of the soft atmospheric pressure chemical ionization 
      source, which results in less fragmentation of the analyte than by conventional 
      electron impact (EI) and chemical ionization (CI) sources, favoring the formation 
      of the [M - Br](+) ion and, thus, enhancing sensitivity and selectivity. 
      Detection was based on the consecutive loses of HBr from the [M - Br](+) ion to 
      form the specific [M - H5Br6](+) and [M - H4Br5](+) ions, which were selected as 
      quantitation (Q) and qualification (q) transitions, respectively. Parameters 
      affecting ionization and MS/MS detection were studied. Method performance was 
      also evaluated; calibration curves were found linear from 1 pg/muL to 100 pg/muL 
      for the total HBCD concentration; instrumental detection limit was estimated to 
      be 0.10 pg/muL; repeatability and reproducibility, expressed as relative standard 
      deviation, were better than 7% in both cases. The application to different real 
      samples [polyurethane foam disks (PUFs), food, and marine samples] pointed out a 
      rapid way to identify and allow quantification of this compound together with a 
      number of polybrominated diphenyl ethers (BDE congeners 28, 47, 66, 85, 99, 100, 
      153, 154, 183, 184, 191, 196, 197, and 209) and two other novel brominated flame 
      retardants [i.e., decabromodiphenyl ethane (DBDPE) and 
      1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE)] because of their presence in the 
      same fraction when performing the usual sample treatment.
FAU - Sales, Carlos
AU  - Sales C
AD  - Research Institute for Pesticides and Water, University Jaume I, 12071, 
      Castellon, Spain.
FAU - Portoles, Tania
AU  - Portoles T
AD  - Research Institute for Pesticides and Water, University Jaume I, 12071, 
      Castellon, Spain.
FAU - Sancho, Juan Vicente
AU  - Sancho JV
AD  - Research Institute for Pesticides and Water, University Jaume I, 12071, 
      Castellon, Spain.
FAU - Abad, Esteban
AU  - Abad E
AD  - Laboratory of Dioxins, IDAEA, CSIC, 08034, Barcelona, Spain.
FAU - Abalos, Manuela
AU  - Abalos M
AD  - Laboratory of Dioxins, IDAEA, CSIC, 08034, Barcelona, Spain.
FAU - Saulo, Jordi
AU  - Saulo J
AD  - Laboratory of Dioxins, IDAEA, CSIC, 08034, Barcelona, Spain.
FAU - Fiedler, Heidelore
AU  - Fiedler H
AD  - UNEP/DTIE Chemicals Branch, 11-13 Chemin des Anemones, 1219, Chatelaine, GE, 
      Switzerland.
AD  - MTM Research Centre, Orebro University, 70182, Orebro, Sweden.
FAU - Gomara, Belen
AU  - Gomara B
AD  - Institute of General Organic Chemistry, CSIC, 28006, Madrid, Spain.
FAU - Beltran, Joaquim
AU  - Beltran J
AD  - Research Institute for Pesticides and Water, University Jaume I, 12071, 
      Castellon, Spain. beltranj@uji.es.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151111
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 5I9835JO3M (hexabromocyclododecane)
SB  - IM
MH  - Animals
MH  - Aquatic Organisms/chemistry
MH  - Decapodiformes
MH  - Dolphins
MH  - Environmental Pollutants/chemistry
MH  - Fishes
MH  - Flame Retardants/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Hydrocarbons, Brominated/*chemistry
MH  - Milk, Human/chemistry
MH  - Molecular Structure
MH  - Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - Atmospheric pressure chemical ionization
OT  - Brominated flame retardants
OT  - Gas chromatography
OT  - Hexabromocyclododecane
OT  - Polyurethane foam (PUF) disks
EDAT- 2015/11/12 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/11/12 06:00
PHST- 2015/08/11 00:00 [received]
PHST- 2015/10/22 00:00 [accepted]
PHST- 2015/10/14 00:00 [revised]
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.1007/s00216-015-9146-8 [pii]
AID - 10.1007/s00216-015-9146-8 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2016 Jan;408(2):449-59. doi: 10.1007/s00216-015-9146-8. Epub 
      2015 Nov 11.