PMID- 26555864
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20180816
IS  - 1362-301X (Electronic)
IS  - 0269-9052 (Linking)
VI  - 30
IP  - 1
DP  - 2016
TI  - Plasma brain-derived neurotrophic factor levels after severe traumatic brain 
      injury.
PG  - 23-8
LID - 10.3109/02699052.2015.1077993 [doi]
AB  - OBJECTIVE: Severe traumatic brain injury (TBI) is associated with a 30-70% 
      mortality rate. Nevertheless, in clinical practice there are no effective 
      biomarkers for the prediction of fatal outcome following severe TBI. Therefore, 
      the aim was to determine whether brain-derived neurotrophic factor (BDNF) plasma 
      levels are associated with intensive care unit (ICU) mortality in patients with 
      severe TBI. METHODS: This prospective study enrolled 120 male patients who 
      suffered severe TBI (Glasgow Coma Scale 3-8 at emergency room admission). The 
      plasma BDNF level was determined at ICU admission (mean 6.4 hours after emergency 
      room admission). RESULTS: Severe TBI was associated with a 35% mortality rate and 
      64% of the patients presented severe TBI with multi-trauma. The mean plasma BDNF 
      concentration among the severe TBI victims was 704.2 +/- 63.4 pg ml(-1) (+/-SEM). 
      Nevertheless, there were no significant differences between BDNF levels in the 
      survivor (700.2 +/- 82.8 pg ml(-1)) or non-survivor (711.6 +/- 97.4 pg ml(-1)) groups 
      (p = 0.238) or in the isolated TBI (800.4 +/- 117.4 pg ml(-1)) or TBI with 
      multi-trauma groups (650.5 +/- 73.9 pg ml(-1)) (p = 0.109). CONCLUSIONS: Plasma 
      BDNF concentrations did not correlate with either short-term fatal outcome or 
      type of injury following severe TBI.
FAU - Simon, Daniel
AU  - Simon D
AD  - a Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude .
AD  - b Laboratorio de Biomarcadores do Trauma , Universidade Luterana do Brasil , 
      Canoas , Brazil , and.
AD  - c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil.
FAU - Nascimento, Rita Iara Moreira do
AU  - Nascimento RI
AD  - a Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude .
FAU - Filho, Edison Moraes Rodrigues
AU  - Filho EM
AD  - a Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude .
FAU - Bencke, Jane
AU  - Bencke J
AD  - b Laboratorio de Biomarcadores do Trauma , Universidade Luterana do Brasil , 
      Canoas , Brazil , and.
FAU - Regner, Andrea
AU  - Regner A
AD  - a Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude .
AD  - b Laboratorio de Biomarcadores do Trauma , Universidade Luterana do Brasil , 
      Canoas , Brazil , and.
AD  - c Curso de Medicina , Universidade Luterana do Brasil , Canoas , Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151110
PL  - England
TA  - Brain Inj
JT  - Brain injury
JID - 8710358
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain Injuries, Traumatic/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF
OT  - biomarker
OT  - multi-trauma
OT  - outcome
OT  - severe TBI
EDAT- 2015/11/12 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/11/12 06:00
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3109/02699052.2015.1077993 [doi]
PST - ppublish
SO  - Brain Inj. 2016;30(1):23-8. doi: 10.3109/02699052.2015.1077993. Epub 2015 Nov 10.