PMID- 26556085 OWN - NLM STAT- MEDLINE DCOM- 20160926 LR - 20191027 IS - 1996-3181 (Electronic) IS - 1871-5273 (Linking) VI - 14 IP - 10 DP - 2015 TI - Potential Therapeutic Effects of Physical Exercise for Bipolar Disorder. PG - 1255-9 AB - Cognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant. Lack of methodological consistency, mainly related to exercise, makes it difficult accuracy and extrapolation of the results. Nevertheless, mechanisms related to BD physiopathology, such as hormonal and neurotransmitters alterations and mainly related to brain-derived neurotrophic factors (BDNF) can be explored. BDNF, specially, have a large influence on brain ability and its gene expression is highly responsive to aerobic exercise. Moreover, aerobic exercise trough BDNF may induce chronic stress suppression, commonly observed in patients with BD, and reduce deleterious effects caused by allostatic loads. Therefore, it is prudent to propose that aerobic exercise plays an important role in BD physiopathological mechanisms and it is a new way for the treatment for this and others psychiatric disorders. FAU - de Sa Filho, Alberto Souza AU - de Sa Filho AS FAU - de Souza Moura, Antonio Marcos AU - de Souza Moura AM FAU - Lamego, Murilo Khede AU - Lamego MK FAU - Ferreira Rocha, Nuno Barbosa AU - Ferreira Rocha NB FAU - Paes, Flavia AU - Paes F FAU - Oliveira, Ana Cristina AU - Oliveira AC FAU - Lattari, Eduardo AU - Lattari E FAU - Rimes, Ridson AU - Rimes R FAU - Manochio, Joao AU - Manochio J FAU - Budde, Henning AU - Budde H FAU - Wegner, Mirko AU - Wegner M FAU - Mura, Gioia AU - Mura G FAU - Arias-Carrion, Oscar AU - Arias-Carrion O FAU - Cheniaux, Elie AU - Cheniaux E FAU - Yuan, Ti-Fei AU - Yuan TF FAU - Nardi, Antonio Egidio AU - Nardi AE FAU - Machado, Sergio AU - Machado S AD - Panic and Respiration Laboratory, Institute of Psychiatry (IPUB) - Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. secm80@gmail.com. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - CNS Neurol Disord Drug Targets JT - CNS & neurological disorders drug targets JID - 101269155 SB - IM MH - Bipolar Disorder/physiopathology/*therapy MH - Exercise/physiology/psychology MH - *Exercise Therapy MH - Humans EDAT- 2015/11/12 06:00 MHDA- 2016/09/27 06:00 CRDT- 2015/11/12 06:00 PHST- 2015/08/30 00:00 [received] PHST- 2015/11/01 00:00 [accepted] PHST- 2015/11/12 06:00 [entrez] PHST- 2015/11/12 06:00 [pubmed] PHST- 2016/09/27 06:00 [medline] AID - CNSNDDT-EPUB-71729 [pii] AID - 10.2174/1871527315666151111122219 [doi] PST - ppublish SO - CNS Neurol Disord Drug Targets. 2015;14(10):1255-9. doi: 10.2174/1871527315666151111122219.