PMID- 26556284
OWN - NLM
STAT- MEDLINE
DCOM- 20160719
LR  - 20181113
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 5
IP  - 11
DP  - 2015 Nov 10
TI  - Effects of deep brain stimulation on prepulse inhibition in obsessive-compulsive 
      disorder.
PG  - e675
LID - 10.1038/tp.2015.171 [doi]
AB  - Owing to a high response rate, deep brain stimulation (DBS) of the ventral 
      striatal area has been approved for treatment-refractory obsessive-compulsive 
      disorder (tr-OCD). Many basic issues regarding DBS for tr-OCD are still not 
      understood, in particular, the mechanisms of action and the origin of side 
      effects. We measured prepulse inhibition (PPI) in treatment-refractory OCD 
      patients undergoing DBS of the nucleus accumbens (NAcc) and matched controls. As 
      PPI has been used in animal DBS studies, it is highly suitable for translational 
      research. Eight patients receiving DBS, eight patients with pharmacological 
      treatment and eight age-matched healthy controls participated in our study. PPI 
      was measured twice in the DBS group: one session with the stimulator switched on 
      and one session with the stimulator switched off. OCD patients in the 
      pharmacologic group took part in a single session. Controls were tested twice, to 
      ensure stability of data. Statistical analysis revealed significant differences 
      between controls and (1) patients with pharmacological treatment and (2) OCD DBS 
      patients when the stimulation was switched off. Switching the stimulator on led 
      to an increase in PPI at a stimulus-onset asynchrony of 200 ms. There was no 
      significant difference in PPI between OCD patients being stimulated and the 
      control group. This study shows that NAcc-DBS leads to an increase in PPI in 
      tr-OCD patients towards a level seen in healthy controls. Assuming that PPI 
      impairments partially reflect the neurobiological substrates of OCD, our results 
      show that DBS of the NAcc may improve sensorimotor gating via correction of 
      dysfunctional neural substrates. Bearing in mind that PPI is based on a complex 
      and multilayered network, our data confirm that DBS most likely takes effect via 
      network modulation.
FAU - Kohl, S
AU  - Kohl S
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Gruendler, T O J
AU  - Gruendler TO
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
AD  - Faculty of Economics, Otto-von-Guericke-University, Magdeburg, Germany.
AD  - Center for Behavioral Brain Sciences, Magdeburg, Germany.
FAU - Huys, D
AU  - Huys D
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Sildatke, E
AU  - Sildatke E
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Dembek, T A
AU  - Dembek TA
AD  - Department of Neurology, University of Cologne, Cologne, Germany.
FAU - Hellmich, M
AU  - Hellmich M
AD  - Institute of Medical Statistics, Informatics, and Epidemiology, University of 
      Cologne, Cologne, Germany.
FAU - Vorderwulbecke, M
AU  - Vorderwulbecke M
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Timmermann, L
AU  - Timmermann L
AD  - Department of Neurology, University of Cologne, Cologne, Germany.
FAU - Ahmari, S E
AU  - Ahmari SE
AD  - Department of Psychiatry, Center for Neuroscience Program, Center for the Neural 
      Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Klosterkoetter, J
AU  - Klosterkoetter J
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Jessen, F
AU  - Jessen F
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Sturm, V
AU  - Sturm V
AD  - Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany.
FAU - Visser-Vandewalle, V
AU  - Visser-Vandewalle V
AD  - Department of Stereotactic and Functional Neurosurgery, University of Cologne, 
      Cologne, Germany.
FAU - Kuhn, J
AU  - Kuhn J
AD  - Department of Psychiatry and Psychotherapy, University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
LA  - eng
GR  - K08 MH087718/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151110
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Adult
MH  - *Deep Brain Stimulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Nucleus Accumbens/*physiopathology
MH  - Obsessive-Compulsive Disorder/*physiopathology/*therapy
MH  - Prepulse Inhibition/*physiology
MH  - Treatment Outcome
PMC - PMC5068764
COIS- JKu has received financial support for IIT studies from Medtronic EuropeSARL 
      (Meerbusch, Germany). VS disclosed financial support for studies and travel to 
      congresses, and lecture fees from Medtronic AG and Advanced Neuromodulation 
      Systems INC. He is also a co-holder of patents on desynchronized brain 
      stimulation and shareholder of ANM-GmbH Juelich, a company that intends to 
      develop new stimulators. The remaining authors declare no conflict of interest.
EDAT- 2015/11/12 06:00
MHDA- 2016/07/20 06:00
PMCR- 2015/11/01
CRDT- 2015/11/12 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/09/14 00:00 [revised]
PHST- 2015/09/19 00:00 [accepted]
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2016/07/20 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - tp2015171 [pii]
AID - 10.1038/tp.2015.171 [doi]
PST - epublish
SO  - Transl Psychiatry. 2015 Nov 10;5(11):e675. doi: 10.1038/tp.2015.171.