PMID- 26556814
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20220408
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 10
IP  - 4
DP  - 2016 Dec
TI  - Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety 
      and depression.
PG  - 1127-1134
AB  - This resting-state functional magnetic resonance imaging (rs-fMRI) study 
      investigated intrinsic brain abnormalities in irritable bowel syndrome (IBS) and 
      effect of anxiety and depression. Thirty IBS patients and 31 matched healthy 
      controls underwent rs-fMRI scanning. Regional brain activity was evaluated by 
      measuring the amplitude of low-frequency fluctuation (ALFF) and compared between 
      IBS patients and healthy controls with a two-sample t-test. Areas with abnormal 
      ALFF were further used as seeds in subsequent inter-regional functional 
      connectivity (FC) analysis. Statistical analyses were also performed by including 
      anxiety and depression as covariates to evaluate their effect. Compared to 
      healthy controls, IBS patients showed decreased ALFF in several core default mode 
      network regions (medial prefrontal cortex [MPFC], posterior cingulate cortex 
      [PCC], bilateral inferior parietal cortices [IPC]), and in middle frontal cortex, 
      right orbital part of the superior frontal gyrus (ORBsup), dorsal anterior 
      cingulate cortex (dACC), and ventral anterior cingulated cortex (vACC), while 
      they showed increased ALFF in bilateral posterior insula and cuneus. In addition, 
      IBS patients revealed decreased inter-regional positive FC between MPFC and right 
      ORBsup, between vACC and PCC, as well as decreased negative FC between MPFC and 
      left posterior insula, while they showed increased negative FC between MPFC and 
      cuneus. The inclusion of anxiety and depression as covariates abolished ALFF 
      differences in dACC and vACC, but none of the FC differences. IN CONCLUSION: IBS 
      patients had disturbed intrinsic brain function. High levels of anxiety and 
      depression in IBS patients could account for their decreased intrinsic brain 
      activity in regions (the ACC) involved in affective processing.
FAU - Qi, Rongfeng
AU  - Qi R
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China.
FAU - Liu, Chang
AU  - Liu C
AD  - Department of Gastroenterology, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China.
FAU - Ke, Jun
AU  - Ke J
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China.
FAU - Xu, Qiang
AU  - Xu Q
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China.
FAU - Zhong, Jianhui
AU  - Zhong J
AD  - Center for Brain Imaging Science and Technology, and Center for Innovative and 
      Collaborative Detection and Treatment of Infectious Diseases, Zhejiang 
      University, Hangzhou, 310027, China.
FAU - Wang, Fangyu
AU  - Wang F
AD  - Department of Gastroenterology, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China.
FAU - Zhang, Long Jiang
AU  - Zhang LJ
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China. kevinzhlj@163.com.
FAU - Lu, Guang Ming
AU  - Lu GM
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 
      210002, China. cjr.luguangming@vip.163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Adult
MH  - Anxiety/diagnostic imaging/*physiopathology
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Depression/diagnostic imaging/*physiopathology
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Irritable Bowel Syndrome/diagnostic imaging/*physiopathology/*psychology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - Rest
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Amplitude of low-frequency fluctuation
OT  - Functional connectivity
OT  - Inter-regional
OT  - Irritable bowel syndrome
OT  - Resting-state functional magnetic resonance imaging
EDAT- 2015/11/12 06:00
MHDA- 2017/10/17 06:00
CRDT- 2015/11/12 06:00
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2015/11/12 06:00 [entrez]
AID - 10.1007/s11682-015-9478-1 [pii]
AID - 10.1007/s11682-015-9478-1 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2016 Dec;10(4):1127-1134. doi: 10.1007/s11682-015-9478-1.