PMID- 26557085
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151111
LR  - 20200930
IS  - 1663-3563 (Print)
IS  - 1663-3563 (Electronic)
IS  - 1663-3563 (Linking)
VI  - 7
DP  - 2015
TI  - Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in 
      Bassoon mutant mice.
PG  - 18
LID - 10.3389/fnsyn.2015.00018 [doi]
LID - 18
AB  - Proper synaptic function depends on a finely-tuned balance between events such as 
      protein synthesis and structural organization. In particular, the functional loss 
      of just one synaptic-related protein can have a profound impact on overall 
      neuronal network function. To this end, we used a mutant mouse model harboring a 
      mutated form of the presynaptic scaffolding protein Bassoon (Bsn), which is 
      phenotypically characterized by: (i) spontaneous generalized epileptic seizure 
      activity, representing a chronically-imbalanced neuronal network; and (ii) a 
      dramatic increase in hippocampal brain-derived neurotrophic factor (BDNF) protein 
      concentration, a key player in synaptic plasticity. Detailed morphological and 
      neurochemical analyses revealed that the increased BDNF levels are associated 
      with: (i) modified neuropeptide distribution; (ii) perturbed expression of 
      selected markers of synaptic activation or plasticity; (iii) subtle changes to 
      microglial structure; and (iv) morphological alterations to the mossy fiber (MF) 
      synapse. These findings emphasize the important contribution of Bassoon protein 
      to normal hippocampal function, and further characterize the Bsn-mutant as a 
      useful model for studying the effects of chronic changes to network activity.
FAU - Dieni, Sandra
AU  - Dieni S
AD  - Neurochemistry Laboratory, Department of Molecular Psychiatry, University 
      Hospital Freiburg Freiburg, Germany.
FAU - Nestel, Sigrun
AU  - Nestel S
AD  - Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of 
      Freiburg Freiburg, Germany.
FAU - Sibbe, Mirjam
AU  - Sibbe M
AD  - Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of 
      Freiburg Freiburg, Germany.
FAU - Frotscher, Michael
AU  - Frotscher M
AD  - Institute for Structural Neurobiology, Center for Molecular Neurobiology Hamburg 
      Hamburg, Germany.
FAU - Hellwig, Sabine
AU  - Hellwig S
AD  - Neurochemistry Laboratory, Department of Molecular Psychiatry, University 
      Hospital Freiburg Freiburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20151023
PL  - Switzerland
TA  - Front Synaptic Neurosci
JT  - Frontiers in synaptic neuroscience
JID - 101548972
PMC - PMC4615824
OTO - NOTNLM
OT  - dense-core vesicle
OT  - hippocampal ultrastructure
OT  - microglia
OT  - mossy fiber bouton
OT  - synaptic plasticity
EDAT- 2015/11/12 06:00
MHDA- 2015/11/12 06:01
PMCR- 2015/01/01
CRDT- 2015/11/12 06:00
PHST- 2015/08/31 00:00 [received]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2015/11/12 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnsyn.2015.00018 [doi]
PST - epublish
SO  - Front Synaptic Neurosci. 2015 Oct 23;7:18. doi: 10.3389/fnsyn.2015.00018. 
      eCollection 2015.