PMID- 26557152
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151111
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2015
DP  - 2015
TI  - Qing Re Liang Xue Decoction Alleviates Hypercoagulability in Kawasaki Disease.
PG  - 864597
LID - 10.1155/2015/864597 [doi]
LID - 864597
AB  - Objective. Kawasaki disease (KD) is a multisystemic autoimmune vasculitis. 
      Intravenous immunoglobulin (IVIG) is the first-line treatment for KD. It is 
      unclear whether traditional Chinese medicine (TCM) has an effect on KD. We aimed 
      to observe the clinical efficacy of TCM on acute KD via serum interleukin-33 
      (IL-33) and tumor necrosis factor alpha (TNF-alpha) measurements. Methods. Thirty-one 
      KD patients were treated with Qing Re Liang Xue decoction and Western medicine 
      (integrative medicine treatment group), while 28 KD patients were treated with 
      Western medicine only (Western medicine treatment group). Thirty patients were 
      included in a febrile group and 28 healthy children were included in the control 
      group. Clinical characteristics and laboratory findings were gathered and 
      compared. Serum IL-33 and TNF-alpha levels were measured by multiplex Luminex assay. 
      Results. The platelet count in the integrative medicine treatment group was 
      significantly lower than that in the Western medicine treatment group. The 
      integrative medicine group had a shorter fever duration and lower IL-33 and TNF-alpha 
      levels than those in the Western medicine group, but there were no significant 
      differences between the two KD groups after treatment. Conclusion. Qing Re Liang 
      Xue decoction improved the hypercoagulable state of KD patients. Potential 
      myocardial protective effects require further research.
FAU - Chen, Jiao-Yang
AU  - Chen JY
AD  - Department of Pediatrics, Beijing Children's Hospital, Capital Medical 
      University, Beijing 100045, China.
FAU - Yin, Ji-Ming
AU  - Yin JM
AD  - Research Department Beijing Institute of Hepatology, Beijing Youan Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Du, Zhong-Dong
AU  - Du ZD
AD  - Department of Pediatrics, Beijing Children's Hospital, Capital Medical 
      University, Beijing 100045, China.
FAU - Hao, Jing
AU  - Hao J
AD  - Department of Pediatrics, Beijing Children's Hospital, Capital Medical 
      University, Beijing 100045, China.
FAU - Yan, Hui-Min
AU  - Yan HM
AD  - Department of Pediatrics, Beijing Children's Hospital, Capital Medical 
      University, Beijing 100045, China.
LA  - eng
PT  - Journal Article
DEP - 20151018
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4628669
EDAT- 2015/11/12 06:00
MHDA- 2015/11/12 06:01
PMCR- 2015/10/18
CRDT- 2015/11/12 06:00
PHST- 2014/12/29 00:00 [received]
PHST- 2015/03/07 00:00 [revised]
PHST- 2015/03/14 00:00 [accepted]
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2015/11/12 06:01 [medline]
PHST- 2015/10/18 00:00 [pmc-release]
AID - 10.1155/2015/864597 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2015;2015:864597. doi: 10.1155/2015/864597. 
      Epub 2015 Oct 18.