PMID- 26558215
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151111
LR  - 20220408
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 8
IP  - 5
DP  - 2015
TI  - Brain-derived neurotrophic factor in patients with advanced age-related macular 
      degeneration.
PG  - 991-5
LID - 10.3980/j.issn.2222-3959.2015.05.25 [doi]
AB  - AIM: To investigate the serum level of the brain-derived neurotrophic factor 
      (BDNF) in age-related macular degeneration (AMD) and healthy control subjects. 
      The disruption in the tight balance of neuroinflammatory and neuroprotective 
      processes in an immune-privileged site like retina is proposed to contribute to 
      the pathogenesis of AMD. One of the main neuroprotective mediators in the central 
      nervous system is BDNF with its serum level notably affected in several 
      neurodegenerative disorders. METHODS: Thirty-six patients with AMD and 36 
      age-matched controls were enrolled in this study. The serum level of BDNF was 
      measured using the enzyme-linked immunosorbent assay method. Results were 
      analyzed to compare case and control values. Comparisons were also made between 
      the BDNF level of wet- vs dry-AMD, and male vs female patients and controls. 
      Analysis of variance (ANOVA) and Student's t-test were employed to analyze the 
      data. RESULTS: The mean BDNF levels in AMD group were significantly higher than 
      the control group. Furthermore, our analysis revealed greater BDNF values in all 
      AMD subgroups compared to controls (P=0.004, 0.005, 0.001 and 0.02 for male 
      wet-AMD, male dry-AMD, female wet-AMD and female dry-AMD vs controls, 
      respectively). The BDNF level however did not vary between wet- and dry-AMD 
      patients (P=0.74). While within-group comparisons in males and females of AMD and 
      control groups did not show any difference in BDNF (P=0.16, 0.64 and 0.85 for 
      wet-AMD, dry-AMD and control groups, respectively), between-group data showed a 
      higher mean BDNF in both male and female AMD subjects than their peer controls. 
      CONCLUSION: This study demonstrated that the serum BDNF level is different in 
      patients with AMD as compared to subjects without AMD. Future attempts should be 
      done to unravel beneficial or deleterious effect of this neurotrophin in the 
      pathogenesis of AMD.
FAU - Afarid, Mehrdad
AU  - Afarid M
AD  - Department of Ophthalmology, Poostchi Eye Research Center, School of Medicine, 
      Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
FAU - Torabi-Nami, Mohammad
AU  - Torabi-Nami M
AD  - Department of Neuroscience, School of Advanced Medical Sciences and Technologies, 
      Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
FAU - Nemati, Alijan
AU  - Nemati A
AD  - Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz 
      71348-14336, Iran.
FAU - Khosravi, Amir
AU  - Khosravi A
AD  - Student Research Committee, Shiraz University of Medical Sciences and Poostchi 
      Eye Research Center, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz 71348-14336, Iran.
FAU - Malekzadeh, Mahyar
AU  - Malekzadeh M
AD  - Institute for Cancer Research, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz 71348-14336, Iran.
LA  - eng
PT  - Journal Article
DEP - 20151018
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC4630989
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - brain-derived neurotrophic factor
OT  - pathogenesis
OT  - serum level
EDAT- 2015/11/12 06:00
MHDA- 2015/11/12 06:01
PMCR- 2015/10/18
CRDT- 2015/11/12 06:00
PHST- 2014/10/01 00:00 [received]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/11/12 06:00 [entrez]
PHST- 2015/11/12 06:00 [pubmed]
PHST- 2015/11/12 06:01 [medline]
PHST- 2015/10/18 00:00 [pmc-release]
AID - ijo-08-05-991 [pii]
AID - 10.3980/j.issn.2222-3959.2015.05.25 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2015 Oct 18;8(5):991-5. doi: 
      10.3980/j.issn.2222-3959.2015.05.25. eCollection 2015.