PMID- 26558429
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20220408
IS  - 1545-7885 (Electronic)
IS  - 1544-9173 (Print)
IS  - 1544-9173 (Linking)
VI  - 13
IP  - 11
DP  - 2015
TI  - Understanding How Exercise Promotes Cognitive Integrity in the Aging Brain.
PG  - e1002300
LID - 10.1371/journal.pbio.1002300 [doi]
LID - e1002300
AB  - Alterations in the structure and organization of the aging central nervous system 
      (CNS), and associated functional deficits, result in cognitive decline and 
      increase susceptibility to neurodegeneration. Age-related changes to the 
      neurovascular unit (NVU), and their consequences for cerebrovascular function, 
      are implicated as driving cognitive impairment during aging as well as in 
      neurodegenerative disease. The molecular events underlying these effects are 
      incompletely characterized. Similarly, the mechanisms underlying effects of 
      factors that reduce the impact of aging on the brain, such as physical exercise, 
      are also opaque. A study in this issue of PLOS Biology links the NVU to cognitive 
      decline in the aging brain and suggests a potential underlying molecular 
      mechanism. Notably, the study further links the protective effects of chronic 
      exercise on cognition to neurovascular integrity during aging.
FAU - Laitman, Benjamin M
AU  - Laitman BM
AD  - Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, United States of America.
FAU - John, Gareth R
AU  - John GR
AD  - Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, United States of America.
LA  - eng
GR  - F30NS090718/NS/NINDS NIH HHS/United States
GR  - R01 NS085103/NS/NINDS NIH HHS/United States
GR  - R01NS085103/NS/NINDS NIH HHS/United States
GR  - F30 NS090718/NS/NINDS NIH HHS/United States
GR  - R01 NS062703/NS/NINDS NIH HHS/United States
GR  - R01NS062703/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151111
PL  - United States
TA  - PLoS Biol
JT  - PLoS biology
JID - 101183755
SB  - IM
CIN - APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and 
      Complement Induction.
MH  - Animals
MH  - Brain/*physiology/physiopathology
MH  - Cognition Disorders/physiopathology/prevention & control
MH  - *Cognitive Aging
MH  - *Exercise
MH  - Humans
MH  - *Models, Cardiovascular
MH  - *Models, Neurological
MH  - Motor Activity
MH  - Neurodegenerative Diseases/physiopathology/prevention & control
MH  - Neurons/*physiology
MH  - *Neurovascular Coupling
PMC - PMC4641709
COIS- The authors have declared that no competing interests exist.
EDAT- 2015/11/13 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/11/11
CRDT- 2015/11/13 06:00
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/11/11 00:00 [pmc-release]
AID - PBIOLOGY-D-15-02586 [pii]
AID - 10.1371/journal.pbio.1002300 [doi]
PST - epublish
SO  - PLoS Biol. 2015 Nov 11;13(11):e1002300. doi: 10.1371/journal.pbio.1002300. 
      eCollection 2015.