PMID- 26558472
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20151112
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 40
IP  - 6
DP  - 2015 Dec
TI  - Effect of in utero exposure to endocrine disruptors on fetal steroidogenesis 
      governed by the pituitary-gonad axis: a study in rats using different ways of 
      administration.
PG  - 909-16
LID - 10.2131/jts.40.909 [doi]
AB  - The effects of endocrine disruptors on testicular steroidogenesis in fetal rats 
      were investigated in a study involving in utero exposure. In the major part of 
      this study, pregnant rats at gestational day (GD)15 were given a single oral 
      administration of the test substance, and then the expression of the following 
      mRNAs in GD20 fetuses was determined: testicular steroidogenic acute-regulatory 
      protein (StAR), a cholesterol transporter mediating the rate-limiting step of 
      steroidogenesis, a ss-subunit of pituitary luteinizing hormone (LH), and a 
      regulator of gonadal steroidogenesis. Among the substances tested, only 
      di(2-ethylhexyl)phthalate (DEHP) reduced the expression of fetal testicular StAR. 
      The others listed below exhibited little effect on fetal StAR: 
      2,2',4,4'-tetrabromodiphenylether, tributyltin chloride, atrazine, permethrin, 
      cadmium chloride (Cd), lead acetate (Pb) and methylmercury (CH3HgOH). None of 
      them, including DEHP, lacked the ability to reduce the expression of pituitary 
      LHss mRNA. The present study also examined the potential of metals as modifiers of 
      fetal steroidogenesis by giving them to pregnant dams in drinking water during 
      GD1 and GD20. Under these conditions, Cd and Pb at a low concentration (0.01 ppm) 
      significantly attenuated the fetal testicular expression of StAR mRNA without a 
      concomitant reduction in LHss. No such effect was detected with CH3HgOH even at 1 
      ppm. These results suggest that: 1) DEHP, Cd and Pb attenuate the fetal 
      production of sex steroids by directly acting on the testis, and 2) chronic 
      treatment during the entire gestational period is more useful than a single 
      administration for determining the hazardous effect of a suspected endocrine 
      disruptor on fetal steroidogenesis.
FAU - Kariyazono, Yudai
AU  - Kariyazono Y
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University.
FAU - Taura, Junki
AU  - Taura J
FAU - Hattori, Yukiko
AU  - Hattori Y
FAU - Ishii, Yuji
AU  - Ishii Y
FAU - Narimatsu, Shizuo
AU  - Narimatsu S
FAU - Fujimura, Masatake
AU  - Fujimura M
FAU - Takeda, Tomoki
AU  - Takeda T
FAU - Yamada, Hideyuki
AU  - Yamada H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Cadmium Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (steroidogenic acute regulatory protein)
RN  - 2P299V784P (Lead)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Cadmium Compounds/toxicity
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Endocrine Disruptors/*toxicity
MH  - Female
MH  - Fetus/*metabolism
MH  - Gonads/*physiology
MH  - Lead/toxicity
MH  - Luteinizing Hormone/genetics/*metabolism
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Maternal-Fetal Exchange
MH  - Phosphoproteins/*metabolism
MH  - Pituitary Gland/*physiology
MH  - Pregnancy
MH  - RNA, Messenger/metabolism
MH  - Rats, Wistar
MH  - Testis/*embryology/*metabolism
EDAT- 2015/11/13 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - 10.2131/jts.40.909 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2015 Dec;40(6):909-16. doi: 10.2131/jts.40.909.