PMID- 26558618
OWN - NLM
STAT- MEDLINE
DCOM- 20160920
LR  - 20221207
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 233
IP  - 4
DP  - 2016 Feb
TI  - Differential effects of 3,4-methylenedioxypyrovalerone (MDPV) and 
      4-methylmethcathinone (mephedrone) in rats trained to discriminate MDMA or a 
      d-amphetamine + MDMA mixture.
PG  - 673-80
LID - 10.1007/s00213-015-4142-4 [doi]
AB  - RATIONALE: Recent reports on the abuse of novel synthetic cathinone derivatives 
      call attention to serious public health risks of these substances. In response to 
      this concern, a growing body of preclinical research has characterized the 
      psychopharmacology of these substances, particularly mephedrone (MEPH) or 
      methylenedioxypyrovalerone (MDPV), noting their similarities to 
      3,4-methylenedioxymethamphetamine (MDMA) and cocaine. Few studies have utilized 
      drug discrimination methodology to characterize the psychopharmacological 
      properties of these substances. OBJECTIVES: The present study employed a rodent 
      drug discrimination assay to further characterize the stimulus effects of MEPH 
      and MDPV in comparison to MDMA and to a drug mixture comprised of d-amphetamine 
      and MDMA. METHODS: Eight male Sprague-Dawley rats were trained to discriminate 
      1.5 mg/kg MDMA, and eight rats were trained to discriminate a mixture of 
      1.5 mg/kg MDMA and 0.5 mg/kg d-amphetamine (MDMA + AMPH) from vehicle. 
      Substitution tests were conducted with MDMA, d-amphetamine, MDPV, MEPH, and 
      cocaine. RESULTS: Dose-response curves generated with MDMA and MEPH were 
      comparable between training groups. In contrast, AMPH, MDPV, and cocaine produced 
      only partial substitution in animals trained to discriminate MDMA but produced 
      full substitution in animals trained to discriminate the MDMA + AMPH mixture. 
      CONCLUSIONS: These findings indicate that MDPV's effects may be more similar to 
      those of traditional psychostimulants, whereas MEPH exerts stimulus effects more 
      similar to those of MDMA. Additional experiments with selective DA and 
      5-hydroxytryptamine (5-HT) receptor antagonists are required to further elucidate 
      specific receptor mechanisms mediating the discriminative stimulus effects of 
      MDPV and mephedrone.
FAU - Harvey, Eric L
AU  - Harvey EL
AD  - Department of Psychology, Western Michigan University, 3754 Wood Hall, Kalamazoo, 
      MI, 49008, USA.
FAU - Baker, Lisa E
AU  - Baker LE
AD  - Department of Psychology, Western Michigan University, 3754 Wood Hall, Kalamazoo, 
      MI, 49008, USA. lisa.baker@wmich.edu.
LA  - eng
GR  - R15 DA038295/DA/NIDA NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20151112
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Benzodioxoles)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Pyrrolidines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - 0 (Synthetic Cathinone)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Benzodioxoles/*pharmacology
MH  - Central Nervous System Stimulants/pharmacology
MH  - Cocaine/pharmacology
MH  - Dextroamphetamine/pharmacology
MH  - Discrimination Learning/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Pyrrolidines/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synthetic Cathinone
PMC - PMC4729611
MID - NIHMS737600
OTO - NOTNLM
OT  - Cocaine
OT  - Drug discrimination
OT  - MDPV
OT  - Mephedrone
OT  - Rats
OT  - d-Amphetamine
EDAT- 2015/11/13 06:00
MHDA- 2016/09/22 06:00
PMCR- 2017/02/01
CRDT- 2015/11/13 06:00
PHST- 2015/01/08 00:00 [received]
PHST- 2015/10/29 00:00 [accepted]
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/09/22 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - 10.1007/s00213-015-4142-4 [pii]
AID - 10.1007/s00213-015-4142-4 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2016 Feb;233(4):673-80. doi: 
      10.1007/s00213-015-4142-4. Epub 2015 Nov 12.