PMID- 26559228
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20191113
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 35
IP  - 3
DP  - 2015
TI  - MHC Genes Linked to Autoimmune Disease.
PG  - 203-51
AB  - Autoimmune diseases (ADs), or autoinflammatoiy diseases, are growing in 
      complexity as diagnoses improve and many factors escalate disease risk. 
      Considerable genetic similarity is found among ADs, and they are frequently 
      associated with major histocompatibility complex (MHC) genes. However, a given 
      disease may be associated with more than one human leukocyte antigen (HLA) 
      allotype, and a given HLA may be associated with more than one AD. The 
      associations of non-MHC genes with AD present an additional problem, and the 
      situation is further complicated by the role that other factors, such as age, 
      diet, therapeutic drugs, and regional influences, play in disease. This review 
      discusses some of the genetics and biochemistry of HLA-linked AD and 
      inflammation, covering some of the best-studied examples and summarizing 
      indicators for class I- and II-mediated disease. However, the scope of this 
      review limits a detailed discussion of all known ADs.
FAU - Deitiker, Philip
AU  - Deitiker P
AD  - Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 
      Houston, Texas.
FAU - Atassi, M Zouhair
AU  - Atassi MZ
AD  - Department of Biochemistry and Molecular Biology, Department of Pathology and 
      Immunology, Baylor College of Medicine, Houston, Texas 77030.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/genetics/*immunology
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 2015/11/13 06:00
MHDA- 2016/08/30 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
AID - 466b6a4e7b66b8cb,10bf5ddc442a0410 [pii]
AID - 10.1615/critrevimmunol.2015014510 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2015;35(3):203-51. doi: 10.1615/critrevimmunol.2015014510.