PMID- 26559800
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20220316
IS  - 0867-7077 (Print)
IS  - 0867-7077 (Linking)
VI  - 83
IP  - 6
DP  - 2015
TI  - Selected molecular events in the pathogenesis of sarcoidosis - recent advances.
PG  - 462-75
LID - 10.5603/PiAP.2015.0076 [doi]
AB  - Sarcoidosis is an orphan inflammatory disorder that can virtually affect any 
      organ or system in the body, although the lungs and lymph nodes are most 
      frequently involved. Sarcoidosis is believed to derive from an interaction 
      between environmental and genetic agents. Many studies emphasize a strong 
      association between certain human leukocyte antigen (HLA) alleles and sarcoidosis 
      susceptibility. Several new insights have allowed the further evaluation of other 
      candidate genes with a potential function in the immunopathogenesis of 
      sarcoidosis. This review summarizes recent advances in the identification of 
      novel molecular markers that may play a role in different stages of disease, such 
      as the acute phase of inflammation, granuloma formation and fibrosis. 
      Furthermore, this article elucidates the role of both TGF-b/Smad and 
      (HIF)-1a-VEGF-ING-4 signaling pathways in the development of sarcoidosis. The 
      potential epigenetic regulation of the processes occurring in sarcoidosis by 
      miRNA is also discussed.
FAU - Kiszalkiewicz, Justyna
AU  - Kiszalkiewicz J
AD  - Department of Molecular Bases of Medicine, 1st Chair of Internal Medicine, 
      Medical University of Lodz, Poland. ewa.brzezianska@umed.lodz.pl.
FAU - Piotrowski, Wojciech J
AU  - Piotrowski WJ
FAU - Brzezianska-Lasota, Ewa
AU  - Brzezianska-Lasota E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Pneumonol Alergol Pol
JT  - Pneumonologia i alergologia polska
JID - 9302892
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*physiology
MH  - Lung/physiopathology
MH  - Sarcoidosis, Pulmonary/*etiology
MH  - Vascular Endothelial Growth Factor A/*physiology
OTO - NOTNLM
OT  - molecular markers
OT  - pathogenesis
OT  - sarcoidosis
EDAT- 2015/11/13 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2015/11/10 00:00 [accepted]
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - VM/OJS/J/43869 [pii]
AID - 10.5603/PiAP.2015.0076 [doi]
PST - ppublish
SO  - Pneumonol Alergol Pol. 2015;83(6):462-75. doi: 10.5603/PiAP.2015.0076.