PMID- 26560898
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20220408
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 116
IP  - 1
DP  - 2016 Jan
TI  - Asthma severity, not asthma control, is worse in atopic compared with nonatopic 
      adolescents with asthma.
PG  - 18-25
LID - S1081-1206(15)00700-0 [pii]
LID - 10.1016/j.anai.2015.10.015 [doi]
AB  - BACKGROUND: The effects of atopic and nonatopic asthma phenotypes on asthma 
      morbidity are unclear. Moreover, asthma morbidity in patients without atopy might 
      be mediated by immunoglobulin E (IgE). OBJECTIVE: To determine differences in 
      morbidity in patients with asthma with and without atopy in a population of 
      inner-city adolescents with asthma and to assess the impact of total IgE (tIgE) 
      in this population. METHODS: Data were obtained from 546 inner-city adolescents 
      in the Asthma Control Evaluation study. A positive skin prick test reaction to 14 
      aeroallergens and specific IgE to 5 aeroallergens determined atopic status. High 
      (>/=75th percentile) and low (</=25th percentile) tIgE levels were categorized. 
      Asthma control (Asthma Control Test) and asthma severity (Composite Asthma 
      Severity Index [CASI]) were measured at multiple time points over 1 year. 
      Fractional exhaled nitric oxide (FeNO) and measurements of morbidity also were 
      collected. Multivariable and repeated measures analyses modeled the relation 
      between atopic status and morbidity. RESULTS: Baseline CASI scores increased 0.90 
      point (P < .05) and FeNO increased 0.85 natural logarithmic unit (P < .001) in 
      participants with vs without atopy. Repeated measures analyses showed consistent 
      results. Participants without atopy and increased tIgE had FeNO 0.73 natural log 
      unit higher (P < .01) than low tIgE and a nonsignificant increase in CASI. The 
      CASI score and FeNO levels were higher for high than for low tIgE in participants 
      with atopy. CONCLUSION: In this population, participants with atopic asthma had 
      worse asthma severity and higher FeNO compared with those with nonatopic asthma, 
      but no difference in control. In all participants, higher tIgE indicated worse 
      severity and higher FeNO. In this population, asthma severity and FeNO might be 
      mediated by IgE in the 2 asthma phenotypes.
CI  - Copyright (c) 2016 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Arroyave, Whitney D
AU  - Arroyave WD
AD  - Tulane University School of Public Health, New Orleans, Louisiana; Social & 
      Scientific Systems, Inc, Silver Spring, Maryland. Electronic address: 
      warroyav@s-3.com.
FAU - Rabito, Felicia A
AU  - Rabito FA
AD  - Tulane University School of Public Health, New Orleans, Louisiana.
FAU - Carlson, John C
AU  - Carlson JC
AD  - Tulane University School of Medicine, New Orleans, Louisiana.
FAU - Sever, Michelle L
AU  - Sever ML
AD  - Rho, Chapel Hill, North Carolina.
FAU - Lefante, John
AU  - Lefante J
AD  - Tulane University School of Public Health, New Orleans, Louisiana.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20151107
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asthma/drug therapy/*immunology/metabolism/physiopathology
MH  - Child
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology/metabolism/physiopathology
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Nitric Oxide/metabolism
MH  - Phenotype
MH  - Skin Tests
EDAT- 2015/11/13 06:00
MHDA- 2016/05/03 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/08/05 00:00 [received]
PHST- 2015/10/09 00:00 [revised]
PHST- 2015/10/11 00:00 [accepted]
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
AID - S1081-1206(15)00700-0 [pii]
AID - 10.1016/j.anai.2015.10.015 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2016 Jan;116(1):18-25. doi: 
      10.1016/j.anai.2015.10.015. Epub 2015 Nov 7.