PMID- 26561536
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2059-268X (Print)
IS  - 2059-268X (Electronic)
VI  - 1
IP  - 3
DP  - 2015 Nov
TI  - MicroRNAs and SIRT1: A Strategy for Stem Cell Renewal and Clinical Development?
PG  - 55-57
AB  - Small non-coding ribonucleic acids (RNAs), known as microRNAs (miRNAs), are now 
      becoming recognized as significant agents that can affect the onset and 
      progression of numerous disorders throughout the body. In particular, miRNAs also 
      may determine stem cell renewal and differentiation. Intimately tied to the 
      ability of miRNAs to govern stem cell proliferation are the proliferative 
      pathways of silent mating type information regulation 2 homolog 1 (Saccharomyces 
      cerevisiae) (SIRT1) and the cell survival mechanisms of autophagy that can be 
      coupled to the activity of the mechanistic target of rapamycin (mTOR). Targeting 
      miRNAs that oversee SIRT1 activity offers interesting prospects for the 
      translation of these pathways into efficacious clinical treatment programs for a 
      host of disorders. Yet, as work in this area progresses, a number of challenges 
      unfold that impact whether manipulation of non-coding RNAs and SIRT1 can finely 
      guide stem cell renewal and differentiation to reach successful clinical 
      outcomes.
FAU - Maiese, Kenneth
AU  - Maiese K
AD  - Cellular and Molecular Signaling, Newark, New Jersey 07101, USA.
LA  - eng
GR  - R01 NS053946/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20151008
PL  - England
TA  - J Transl Sci
JT  - Journal of translational science
JID - 101661355
PMC - PMC4638174
MID - NIHMS732980
OTO - NOTNLM
OT  - Akt
OT  - FoxO
OT  - SIRT1
OT  - apoptosis
OT  - autophagy
OT  - forkhead
OT  - mTOR
OT  - mTORC1
OT  - mTORC2
OT  - miRNA
OT  - programmed cell death
OT  - sirtuins
OT  - small non-coding RNA
OT  - stem cells
EDAT- 2015/11/13 06:00
MHDA- 2015/11/13 06:01
PMCR- 2015/11/09
CRDT- 2015/11/13 06:00
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2015/11/13 06:01 [medline]
PHST- 2015/11/09 00:00 [pmc-release]
PST - ppublish
SO  - J Transl Sci. 2015 Nov;1(3):55-57. Epub 2015 Oct 8.