PMID- 26561607
OWN - NLM
STAT- MEDLINE
DCOM- 20161018
LR  - 20181113
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 115
IP  - 1
DP  - 2016 Jan 1
TI  - Balanced ionotropic receptor dynamics support signal estimation via 
      voltage-dependent membrane noise.
PG  - 530-45
LID - 10.1152/jn.00786.2015 [doi]
AB  - Encoding behaviorally relevant stimuli in a noisy background is critical for 
      animals to survive in their natural environment. We identify core biophysical and 
      synaptic mechanisms that permit the encoding of low-frequency signals in 
      pyramidal neurons of the weakly electric fish Apteronotus leptorhynchus, an 
      animal that can accurately encode even miniscule amplitude modulations of its 
      self-generated electric field. We demonstrate that slow NMDA receptor 
      (NMDA-R)-mediated excitatory postsynaptic potentials (EPSPs) are able to summate 
      over many interspike intervals (ISIs) of the primary electrosensory afferents 
      (EAs), effectively eliminating the baseline EA ISI correlations from the 
      pyramidal cell input. Together with a dynamic balance of NMDA-R and GABA-A-R 
      currents, this permits stimulus-evoked changes in EA spiking to be transmitted 
      efficiently to target electrosensory lobe (ELL) pyramidal cells, for encoding 
      low-frequency signals. Interestingly, AMPA-R activity is depressed and appears to 
      play a negligible role in the generation of action potentials. Instead, we 
      hypothesize that cell-intrinsic voltage-dependent membrane noise supports the 
      encoding of perithreshold sensory input; this noise drives a significant 
      proportion of pyramidal cell spikes. Together, these mechanisms may be sufficient 
      for the ELL to encode signals near the threshold of behavioral detection.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Marcoux, Curtis M
AU  - Marcoux CM
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Ontario, Canada;
FAU - Clarke, Stephen E
AU  - Clarke SE
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Ontario, Canada;
FAU - Nesse, William H
AU  - Nesse WH
AD  - Department of Mathematics, University of Utah, Salt Lake City, Utah;
FAU - Longtin, Andre
AU  - Longtin A
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Ontario, Canada; Department of Physics, University of Ottawa, Ottawa, Ontario, 
      Canada; and Brain and Mind Institute and Center for Neural Dynamics, University 
      of Ottawa, Ottawa, Ontario, Canada.
FAU - Maler, Leonard
AU  - Maler L
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Ontario, Canada; Brain and Mind Institute and Center for Neural Dynamics, 
      University of Ottawa, Ottawa, Ontario, Canada lmaler@uottawa.ca.
LA  - eng
GR  - 49510/Canadian Institutes of Health Research/Canada
GR  - 6027/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151111
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, GABA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Afferent Pathways/*physiology
MH  - Animals
MH  - Electric Fish
MH  - Electric Stimulation
MH  - Female
MH  - Male
MH  - Pyramidal Cells/*physiology
MH  - Receptors, AMPA/*physiology
MH  - Receptors, GABA/*physiology
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
MH  - *Synaptic Potentials
PMC - PMC4760475
OTO - NOTNLM
OT  - NMDA receptor
OT  - correlations
OT  - electric fish
OT  - signal detection
OT  - spike train
OT  - stochastic resonance
EDAT- 2015/11/13 06:00
MHDA- 2016/10/19 06:00
PMCR- 2017/01/01
CRDT- 2015/11/13 06:00
PHST- 2015/08/10 00:00 [received]
PHST- 2015/11/10 00:00 [accepted]
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/10/19 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - jn.00786.2015 [pii]
AID - JN-00786-2015 [pii]
AID - 10.1152/jn.00786.2015 [doi]
PST - ppublish
SO  - J Neurophysiol. 2016 Jan 1;115(1):530-45. doi: 10.1152/jn.00786.2015. Epub 2015 
      Nov 11.