PMID- 26561625
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20230318
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Linking)
VI  - 102
IP  - 6
DP  - 2015 Dec
TI  - Psyllium fiber improves glycemic control proportional to loss of glycemic 
      control: a meta-analysis of data in euglycemic subjects, patients at risk of type 
      2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus.
PG  - 1604-14
LID - 10.3945/ajcn.115.106989 [doi]
AB  - BACKGROUND: A number of health benefits are associated with intake of soluble, 
      viscous, gel-forming fibers, including reduced serum cholesterol and the 
      attenuation of postprandial glucose excursions. OBJECTIVE: We assess the effects 
      of psyllium, which is a soluble, gel-forming, nonfermented fiber supplement, on 
      glycemic control in patients who were being treated for type 2 diabetes mellitus 
      (T2DM) and in patients who were at risk of developing T2DM. DESIGN: A 
      comprehensive search was performed of available published literature (Scopus 
      scientific database) and clinical records stored by Procter & Gamble with the use 
      of key search terms to identify clinical studies that assessed the glycemic 
      effects of psyllium in nondiabetic, pre-T2DM, and T2DM patients. RESULTS: We 
      identified 35 randomized, controlled, clinical studies that spanned 3 decades and 
      3 continents. These data were assessed in 8 meta-analyses. In patients with T2DM, 
      multiweek studies (psyllium dosed before meals) showed significant improvement in 
      both the fasting blood glucose (FBG) concentration (-37.0 mg/dL; P < 0.001) and 
      glycated hemoglobin (HbA1c) [-0.97% (-10.6 mmol/mol); P = 0.048]. Glycemic 
      effects were proportional to baseline FBG; no significant glucose lowering was 
      observed in euglycemic subjects, a modest improvement was observed in subjects 
      with pre-T2DM, and the greatest improvement was observed in subjects who were 
      being treated for T2DM. CONCLUSIONS: These data indicate that psyllium would be 
      an effective addition to a lifestyle-intervention program. The degree of 
      psyllium's glycemic benefit was commensurate with the loss of glycemic control. 
      Because the greatest effect was seen in patients who were being treated for T2DM, 
      additional studies are needed to determine how best to incorporate psyllium into 
      existing prevention and treatment algorithms with concomitant hypoglycemic 
      medications.
CI  - (c) 2015 American Society for Nutrition.
FAU - Gibb, Roger D
AU  - Gibb RD
AD  - Procter & Gamble Co., Mason, OH; and gibb.rd@pg.com.
FAU - McRorie, Johnson W Jr
AU  - McRorie JW Jr
AD  - Procter & Gamble Co., Mason, OH; and.
FAU - Russell, Darrell A
AU  - Russell DA
AD  - Procter & Gamble Co., Mason, OH; and.
FAU - Hasselblad, Vic
AU  - Hasselblad V
AD  - Department of Biostatistics and Bioinformatics and.
FAU - D'Alessio, David A
AU  - D'Alessio DA
AD  - Division of Endocrinology, Metabolism and Nutrition, Duke Department of Medicine, 
      Duke University, Durham, NC.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20151111
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Prebiotics)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 8063-16-9 (Psyllium)
SB  - IM
MH  - Combined Modality Therapy/adverse effects
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/prevention & control/*therapy
MH  - *Evidence-Based Medicine
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperglycemia/*prevention & control
MH  - Hypoglycemia/*prevention & control
MH  - *Prebiotics/adverse effects
MH  - Prediabetic State/blood/*diet therapy/epidemiology/prevention & control
MH  - Psyllium/adverse effects/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Risk
OTO - NOTNLM
OT  - diabetes
OT  - fiber
OT  - glycemic
OT  - glycemic control
OT  - meta-analysis
OT  - metabolic syndrome
OT  - psyllium
OT  - type 2 diabetes
EDAT- 2015/11/13 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - S0002-9165(23)27235-4 [pii]
AID - 10.3945/ajcn.115.106989 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2015 Dec;102(6):1604-14. doi: 10.3945/ajcn.115.106989. Epub 2015 
      Nov 11.