PMID- 26562135
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20220321
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 233
IP  - 7
DP  - 2016 Jul
TI  - [Correlation from Undiluted Vitreous Cytokines of Untreated Central Retinal Vein 
      Occlusion with Spectral Domain Optical Coherence Tomography].
PG  - 864-8
LID - 10.1055/s-0041-105408 [doi]
AB  - PURPOSE: To correlate key inflammatory and pro-angiogenic cytokines from 
      undiluted vitreous fluid of treatment-naive patients with central retinal vein 
      occlusion (CRVO) with SD-OCT parameters. METHODS: Thirty-five patients (age 71.1 
      years, 24 phakic, 30 non-ischaemic) underwent intravitreal combination therapy, 
      including single-site 23-gauge core vitrectomy. Twenty-eight samples from 
      patients with idiopathic, non-uveitis floaterectomy served as controls. Levels of 
      interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and vascular 
      endothelial growth factor (VEGF-A) were correlated with visual acuity (logMar), 
      category of CRVO (ischaemic or non-ischaemic) and morphological parameters, such 
      as central macular thickness (CMT), thickness of neurosensory retina (Tneuro), 
      extent of serous retinal detachment (SRT) and disintegrity of the IS/OS and 
      others. RESULTS: Mean IL-6 was 64.7 pg/ml (SD +/- 115.8), mean MCP-1 1015.7 pg/ml 
      (+/- 970.1), and mean VEGF-A 278.4 pg/ml (+/- 512.8), which was significantly higher 
      than the control values of IL-6 6.2 +/- 3.4 pg/ml (p = 0.06), MCP-1 
      253.2 +/- 73.5 pg/ml (p < 0.0 000 001) and VEGF-A 7.0 +/- 4.9 pg/ml (p < 0.0006), 
      respectively. All cytokines correlated highly with one another (correlation 
      coefficient r = 0.82 for IL-6 and MCP-1; r = 0.68 for Il-6 and VEGF-A; r = 0.64 
      for MCP-1 and VEGF-A). IL-6 correlated significantly with CMT, TRT, SRT, dIS/OS, 
      and dELM. MCP-1 correlated significantly with SRT, dIS/OS, and dELM. VEGF-A did 
      not correlate with changes in SD-OCT, while it had a trend to be higher in the 
      ischaemic versus the non-ischaemic CRVO groups (p = 0.09). CONCLUSIONS: The 
      inflammatory cytokines were more often correlated with morphological changes 
      assessed by SD-OCT, whereas VEGF-A did not correlate with CRVO-associated changes 
      in SD-OCT. VEGF inhibition alone may not be sufficient to decrease the 
      inflammatory response in CRVO therapy.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Dacheva, I
AU  - Dacheva I
AD  - Augenklinik, Universitat Heidelberg.
FAU - Ceglowska, K
AU  - Ceglowska K
AD  - Augenklinik, Universitat Heidelberg.
FAU - Nobl, M
AU  - Nobl M
AD  - Augenklinik, Universitat Heidelberg.
FAU - Nowomiejska, K
AU  - Nowomiejska K
AD  - Department of General Ophthalmology, Medical University of Lublin, Poland.
FAU - Kretz, F T
AU  - Kretz FT
AD  - Augenklinik, Universitat Heidelberg.
FAU - Reich, M
AU  - Reich M
AD  - Augenklinik, Universitat Heidelberg.
FAU - Deuchler, S
AU  - Deuchler S
AD  - Augenklinik, Universitatsklinikum Frankfurt.
FAU - Tandogan, T
AU  - Tandogan T
AD  - Augenklinik, Universitat Heidelberg.
FAU - Auffarth, G U
AU  - Auffarth GU
AD  - Augenklinik, Universitat Heidelberg.
FAU - Koss, M J
AU  - Koss MJ
AD  - Augenklinik, Universitat Heidelberg.
LA  - ger
PT  - Journal Article
TT  - Korrelation von intravitrealen Zytokinen und OCT-Parametern bei 
      Zentralvenenverschluss.
DEP - 20151112
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Cytokines/*immunology
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Inflammation Mediators/*immunology
MH  - Male
MH  - Reproducibility of Results
MH  - Retinal Vein Occlusion/diagnostic imaging/*immunology/*pathology
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - Tomography, Optical Coherence/*methods
MH  - Vitreous Body/*immunology
EDAT- 2015/11/13 06:00
MHDA- 2017/08/19 06:00
CRDT- 2015/11/13 06:00
PHST- 2015/11/13 06:00 [entrez]
PHST- 2015/11/13 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
AID - 10.1055/s-0041-105408 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2016 Jul;233(7):864-8. doi: 10.1055/s-0041-105408. Epub 
      2015 Nov 12.