PMID- 26563739 OWN - NLM STAT- MEDLINE DCOM- 20170504 LR - 20181202 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 99 IP - Pt B DP - 2017 Feb TI - Using interstimulus interval to maximise sensitivity of the Psychomotor Vigilance Test to fatigue. PG - 406-410 LID - S0001-4575(15)30092-0 [pii] LID - 10.1016/j.aap.2015.10.013 [doi] AB - There is some evidence that short interstimulus intervals (ISIs) on the Psychomotor Vigilance Test (PVT) are associated with longer and more varied reaction times (RTs). Preparation processes may impede RT following short ISIs, resulting in additional unexplained variance. The aims of this study were to investigate whether there is an effect of ISI on RT and errors within the PVT, and whether such an effect changes with three elements of fatigue: time of day, prior wake and time on task. Twelve male participants completed 49 PVTs across 7x 28h periods of forced desynchrony. For analysis, RTs, reciprocal reaction times (1/RT), false starts and lapse responses within each 10min session were assigned to a 1-s ISI group, a 2-min time of task group, a 2.5-h PW level and a 60 degrees phase of the circadian rhythm of core body temperature (as a measure of time of day). Responses following short ISIs (2-5s) were significantly slower and more varied than responses following longer ISIs (5-10s). The likelihood of a lapse was also higher for short ISIs, while the probability of a false start increased as a function of ISI. These effects were independent of the influences of time of day, prior wake and time on task. Hence, mixed model ANOVAs comprising only long ISIs (5-10s) contained stronger effect sizes for fatigue than a model of all ISIs (2-10s). Including an ISI variable in a model improved the model fit and explained more variance associated with fatigue. Short ISIs resulted in long RTs both in the presence and absence of fatigue, possibly due to preparation processes or ISI conditioning. Hence, omitting short ISI trials from RT means or including an ISI variable in analysis can reduce unwanted variance in PVT data, improving the sensitivity of the PVT to fatigue. CI - Copyright (c) 2015 Elsevier Ltd. All rights reserved. FAU - Matthews, Raymond W AU - Matthews RW AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia; Centre for Sleep Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. Electronic address: r.w.matthews@cqu.edu.au. FAU - Ferguson, Sally A AU - Ferguson SA AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia. Electronic address: sally.ferguson@cqu.edu.au. FAU - Sargent, Charli AU - Sargent C AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia. Electronic address: charli.sargent@cqu.edu.au. FAU - Zhou, Xuan AU - Zhou X AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia. Electronic address: x.zhou@cqu.edu.au. FAU - Kosmadopoulos, Anastasi AU - Kosmadopoulos A AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia. Electronic address: a.kosmadopoulos@cqu.edu.au. FAU - Roach, Gregory D AU - Roach GD AD - Appleton Institute for Behavioural Science, Central Queensland University, PO Box 42, Goodwood, South Australia 5032, Australia. Electronic address: greg.roach@cqu.edu.au. LA - eng PT - Journal Article DEP - 20151110 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Adult MH - Circadian Rhythm/*physiology MH - Fatigue/*physiopathology MH - Humans MH - Male MH - Psychomotor Performance/*physiology MH - Reaction Time/*physiology MH - Sleep Deprivation/physiopathology MH - Wakefulness/physiology OTO - NOTNLM OT - Fatigue OT - Forced desynchrony OT - Neurocognitive performance OT - Preparedness OT - Psychomotor Vigilance Task OT - Sleep EDAT- 2015/11/14 06:00 MHDA- 2017/05/05 06:00 CRDT- 2015/11/14 06:00 PHST- 2015/06/28 00:00 [received] PHST- 2015/10/04 00:00 [revised] PHST- 2015/10/13 00:00 [accepted] PHST- 2015/11/14 06:00 [pubmed] PHST- 2017/05/05 06:00 [medline] PHST- 2015/11/14 06:00 [entrez] AID - S0001-4575(15)30092-0 [pii] AID - 10.1016/j.aap.2015.10.013 [doi] PST - ppublish SO - Accid Anal Prev. 2017 Feb;99(Pt B):406-410. doi: 10.1016/j.aap.2015.10.013. Epub 2015 Nov 10.