PMID- 26564998
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20220410
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 22
IP  - 10
DP  - 2016 Sep
TI  - A comparative analysis of Patient-Reported Expanded Disability Status Scale 
      tools.
PG  - 1349-58
LID - 10.1177/1352458515616205 [doi]
AB  - BACKGROUND: Patient-Reported Expanded Disability Status Scale (PREDSS) tools are 
      an attractive alternative to the Expanded Disability Status Scale (EDSS) during 
      long term or geographically challenging studies, or in pressured clinical service 
      environments. OBJECTIVES: Because the studies reporting these tools have used 
      different metrics to compare the PREDSS and EDSS, we undertook an individual 
      patient data level analysis of all available tools. METHODS: Spearman's rho and 
      the Bland-Altman method were used to assess correlation and agreement 
      respectively. RESULTS: A systematic search for validated PREDSS tools covering 
      the full EDSS range identified eight such tools. Individual patient data were 
      available for five PREDSS tools. Excellent correlation was observed between EDSS 
      and PREDSS with all tools. A higher level of agreement was observed with 
      increasing levels of disability. In all tools, the 95% limits of agreement were 
      greater than the minimum EDSS difference considered to be clinically significant. 
      However, the intra-class coefficient was greater than that reported for EDSS 
      raters of mixed seniority. The visual functional system was identified as the 
      most significant predictor of the PREDSS-EDSS difference. CONCLUSION: This 
      analysis will (1) enable researchers and service providers to make an informed 
      choice of PREDSS tool, depending on their individual requirements, and (2) 
      facilitate improvement of current PREDSS tools.
CI  - (c) The Author(s), 2015.
FAU - Collins, Christian DE
AU  - Collins CD
AD  - Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, 
      University of Southampton, Southampton General Hospital, Southampton, UK.
FAU - Ivry, Ben
AU  - Ivry B
AD  - Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, 
      University of Southampton, Southampton General Hospital, Southampton, UK.
FAU - Bowen, James D
AU  - Bowen JD
AD  - Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA.
FAU - Cheng, Eric M
AU  - Cheng EM
AD  - Department of Neurology, David Geffen School of Medicine, VA Greater Los Angeles 
      Healthcare System, University of California, Los Angeles (UCLA), Los Angeles, CA, 
      USA.
FAU - Dobson, Ruth
AU  - Dobson R
AD  - Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen 
      Mary University of London, London, UK.
FAU - Goodin, Douglas S
AU  - Goodin DS
AD  - Department of Neurology, University of California, San Francisco (UCSF), San 
      Francisco, CA, USA.
FAU - Lechner-Scott, Jeannette
AU  - Lechner-Scott J
AD  - Hunter Medical Research Institute, The University of Newcastle, Australia and 
      Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
FAU - Kappos, Ludwig
AU  - Kappos L
AD  - Departments of Medicine, Clinical Research, Biomedicine and Biomedical 
      Engineering, University Hospital Basel, Basel, Switzerland.
FAU - Galea, Ian
AU  - Galea I
AD  - Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, 
      University of Southampton, Southampton General Hospital, Southampton, UK/Wessex 
      Neurosciences Centre, University Hospital Southampton NHS Foundation Trust, 
      Southampton, UK I.Galea@soton.ac.uk.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151112
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - *Disability Evaluation
MH  - Humans
MH  - Multiple Sclerosis/*physiopathology
MH  - *Patient Reported Outcome Measures
PMC - PMC5015760
OTO - NOTNLM
OT  - Expanded disability status scale
OT  - Kurtzke scale
OT  - Neurostatus
OT  - Patient-reported Expanded Disability Status Scale
OT  - multiple sclerosis
OT  - patient reported
OT  - self administered
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship and/or publication of this article.
EDAT- 2015/11/14 06:00
MHDA- 2018/01/18 06:00
PMCR- 2016/09/08
CRDT- 2015/11/14 06:00
PHST- 2015/07/09 00:00 [received]
PHST- 2015/09/30 00:00 [accepted]
PHST- 2015/11/14 06:00 [entrez]
PHST- 2015/11/14 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2016/09/08 00:00 [pmc-release]
AID - 1352458515616205 [pii]
AID - 10.1177_1352458515616205 [pii]
AID - 10.1177/1352458515616205 [doi]
PST - ppublish
SO  - Mult Scler. 2016 Sep;22(10):1349-58. doi: 10.1177/1352458515616205. Epub 2015 Nov 
      12.