PMID- 26565601
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20220316
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 36
IP  - 12
DP  - 2015 Dec
TI  - Effects of selective reduced uterine perfusion pressure in pregnant rats.
PG  - 1450-4
LID - S0143-4004(15)30077-1 [pii]
LID - 10.1016/j.placenta.2015.10.017 [doi]
AB  - INTRODUCTION: To assess the effects of selective reduced uterine perfusion 
      pressure (SRUPP) in pregnant rats. METHODS: 20 pregnant Sprague-Dawley rats were 
      allocated either to an intervention group, exposed to SRUPP (n = 10) or a control 
      group, exposed to sham surgery (n = 10). Such procedures were performed on 
      gestational day (GD) 14. The Mean arterial pressure (MAP) was measured on GD14 
      (before surgery) and GD20. We measured 18 h proteinuria on GD20. On GD21, mean 
      fetal (MFW) and placental (MPW) weights were obtained. Oxidative stress and 
      angiogenic markers were measured in placental tissue and urine. Mann Whitney U or 
      Independent samples T test were used when appropriate. A two-sided P < 0.05 
      indicated statistical significance. RESULTS: MAP on GD20 was higher in the 
      intervention group (109 +/- 1.7 mmHg) when compared with the control group (83 +/- 
      1.5 mmHg) (P = 0.002). There was no significant difference in urinary protein 
      excretion (117 +/- 3.1 mg/24 h versus 136 mg +/- 2.8/24 h, P = 0.18), MFW (4.14 +/- 
      0.05 versus 4.39 +/- 0.04 g, P = 0.19) or MPW (0.43 +/- 0.008 versus 0.44 +/- 0.006 g, 
      P = 0.73) between the intervention and the control groups, respectively. The 
      oxidative stress was increased; whereas, the sFLT1 expression was not increased 
      when the SRUPP group was compared with controls. DISCUSSION: SRUPP is associated 
      with an increase in maternal MAP and oxidative stress and therefore it may become 
      a useful tool in the study of pregnancy-related hypertensive disorders.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Schenone, Mauro H
AU  - Schenone MH
AD  - Department of Obstetrics and Gynecology, University of Tennessee Health Science 
      Center, 853 Jefferson Ave, Room E102., Memphis, 38163, TN, USA. Electronic 
      address: mschenon@uthsc.edu.
FAU - Mari, Giancarlo
AU  - Mari G
AD  - Department of Obstetrics and Gynecology, University of Tennessee Health Science 
      Center, 853 Jefferson Ave, Room E102., Memphis, 38163, TN, USA.
FAU - Schlabritz-Loutsevitch, Natalia
AU  - Schlabritz-Loutsevitch N
AD  - Department of Obstetrics and Gynecology, University of Tennessee Health Science 
      Center, 853 Jefferson Ave, Room E102., Memphis, 38163, TN, USA.
FAU - Ahokas, Robert
AU  - Ahokas R
AD  - Department of Obstetrics and Gynecology, University of Tennessee Health Science 
      Center, 853 Jefferson Ave, Room E102., Memphis, 38163, TN, USA.
LA  - eng
PT  - Journal Article
DEP - 20151028
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blood Pressure
MH  - Disease Models, Animal
MH  - Female
MH  - Oxidative Stress/physiology
MH  - Perfusion
MH  - Placenta/*metabolism/physiopathology
MH  - Pre-Eclampsia/*metabolism/physiopathology
MH  - Pregnancy
MH  - Proteinuria/*metabolism/physiopathology
MH  - Rats, Sprague-Dawley
MH  - Uterus/*metabolism/physiopathology
OTO - NOTNLM
OT  - Gestational
OT  - Hypertension
OT  - Model
OT  - Preeclampsia
OT  - Rat
EDAT- 2015/11/14 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/11/14 06:00
PHST- 2015/04/26 00:00 [received]
PHST- 2015/10/17 00:00 [revised]
PHST- 2015/10/23 00:00 [accepted]
PHST- 2015/11/14 06:00 [entrez]
PHST- 2015/11/14 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S0143-4004(15)30077-1 [pii]
AID - 10.1016/j.placenta.2015.10.017 [doi]
PST - ppublish
SO  - Placenta. 2015 Dec;36(12):1450-4. doi: 10.1016/j.placenta.2015.10.017. Epub 2015 
      Oct 28.