PMID- 26566410
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151114
LR  - 20200930
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 7
IP  - 12
DP  - 2015 Dec
TI  - The Diagnosis of Choriocarcinoma in Molar Pregnancies: A Revised Approach in 
      Clinical Testing.
PG  - 961-6
LID - 10.14740/jocmr2236w [doi]
AB  - BACKGROUND: Hydatidiform moles occur in approximately 1 in 1,500 pregnancies; 
      however, early miscarriages or spontaneous abortions may not be correctly 
      identified as molar pregnancies due to poor differentiation of chorionic villi. 
      METHODS: The current clinical testing algorithm used for the detection of 
      hydatidiform moles uses a combination of morphological analysis and p57 
      immunostaining followed by ploidy testing to establish a diagnosis of either a 
      complete or partial molar pregnancy. We review here 198 referrals for 
      fluorescence in situ hybridization (FISH) ploidy testing, where the initial 
      diagnosis based on morphology is compared to the final diagnosis based on a 
      combination of morphology, FISH and p57 immunohistochemical (IHC) staining. 
      RESULTS: Approximately 40% of cases were determined to be genetically abnormal, 
      but only 28.8% of cases were diagnosed as molar pregnancies. The underestimation 
      of complete molar pregnancies and those with androgenetic inheritance was also 
      found to be likely using conventional diagnostic methods, as atypical p57 
      staining was observed in approximately 10% of cases. CONCLUSIONS: Our findings 
      suggest that a revised approach to testing products of conception is necessary, 
      with cases screened according to their clinical history in order to distinguish 
      molar pregnancy referrals from hydropic pregnancies.
FAU - Duffy, Lisa
AU  - Duffy L
AD  - Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland, New Zealand.
FAU - Zhang, Liangtao
AU  - Zhang L
AD  - Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland, New Zealand.
FAU - Sheath, Karen
AU  - Sheath K
AD  - Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland, New Zealand.
FAU - Love, Donald R
AU  - Love DR
AD  - Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland, New Zealand.
FAU - George, Alice M
AU  - George AM
AD  - Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland, New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20151023
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC4625817
OTO - NOTNLM
OT  - Fluorescence in situ hybridization
OT  - Hydatidiform moles
OT  - Molar pregnancies
OT  - Ploidy
EDAT- 2015/11/14 06:00
MHDA- 2015/11/14 06:01
PMCR- 2015/10/23
CRDT- 2015/11/14 06:00
PHST- 2015/07/06 00:00 [accepted]
PHST- 2015/11/14 06:00 [entrez]
PHST- 2015/11/14 06:00 [pubmed]
PHST- 2015/11/14 06:01 [medline]
PHST- 2015/10/23 00:00 [pmc-release]
AID - 10.14740/jocmr2236w [doi]
PST - ppublish
SO  - J Clin Med Res. 2015 Dec;7(12):961-6. doi: 10.14740/jocmr2236w. Epub 2015 Oct 23.