PMID- 26567727
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20181113
IS  - 1745-7254 (Electronic)
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 36
IP  - 12
DP  - 2015 Dec
TI  - Formation of aversive memories associated with conditioned drug withdrawal 
      requires BDNF expression in the amygdala in acute morphine-dependent rats.
PG  - 1437-43
LID - 10.1038/aps.2015.94 [doi]
AB  - AIM: Brain-derived neurotrophic factor (BDNF) plays an important role in learning 
      and memory in multiple brain areas. In the present study, we investigated the 
      roles of BDNF in aversive memories associated with conditioned drug withdrawal in 
      acute morphine-dependent rats. METHODS: Conditioned place aversion (CPA) was 
      induced in male SD rats exposed to a single dose of morphine (10 mg/kg, sc) 
      followed by naloxone (0.3 mg/kg, sc). In some rats, BDNF receptor antagonist 
      K252a (8.5 ng per side) or BDNF scavenger TrkB-FC (0.65 mug per side) was 
      bilaterally microinjected into amygdala before naloxone injection. BDNF mRNA and 
      protein expression levels in amygdala were detected after the behavior testing. 
      RESULTS: CPA behavior was induced in rats by the naloxone-precipitated morphine 
      withdrawal, which was accompanied by significantly increased levels of BDNF mRNA 
      and protein in the amygdala. Bilateral microinjection of TrkB-FC or K252a into 
      the amygdala completely blocked CPA behavior in the rats. CONCLUSION: Formation 
      of aversive memories associated with conditioned drug withdrawal in acute 
      morphine-dependent rats requires BDNF expression in the amygdala.
FAU - Ju, Yun-yue
AU  - Ju YY
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201203, China.
FAU - Long, Jian-dong
AU  - Long JD
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201203, China.
FAU - Liu, Yao
AU  - Liu Y
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201203, China.
FAU - Liu, Jing-gen
AU  - Liu JG
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Sciences, Shanghai 201203, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151116
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Narcotics)
RN  - 0 (RNA, Messenger)
RN  - 36B82AMQ7N (Naloxone)
RN  - 76I7G6D29C (Morphine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Amygdala/*drug effects/metabolism/physiopathology
MH  - Animals
MH  - Aversive Therapy
MH  - Male
MH  - Morphine/adverse effects
MH  - Morphine Dependence/*genetics/physiopathology/*therapy
MH  - Naloxone/*therapeutic use
MH  - Narcotic Antagonists/*therapeutic use
MH  - Narcotics/adverse effects
MH  - RNA, Messenger/genetics
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*genetics
MH  - Substance Withdrawal Syndrome/*genetics/physiopathology
MH  - Up-Regulation
PMC - PMC4816238
EDAT- 2015/11/17 06:00
MHDA- 2016/08/19 06:00
PMCR- 2015/12/01
CRDT- 2015/11/17 06:00
PHST- 2015/04/27 00:00 [received]
PHST- 2015/08/14 00:00 [accepted]
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - aps201594 [pii]
AID - 10.1038/aps.2015.94 [doi]
PST - ppublish
SO  - Acta Pharmacol Sin. 2015 Dec;36(12):1437-43. doi: 10.1038/aps.2015.94. Epub 2015 
      Nov 16.