PMID- 26567758
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1880-2206 (Electronic)
IS  - 1347-3182 (Print)
IS  - 1347-3182 (Linking)
VI  - 15
IP  - 2
DP  - 2016
TI  - Low WSS and High OSI Measured by 3D Cine PC MRI Reflect High Pulmonary Artery 
      Pressures in Suspected Secondary Pulmonary Arterial Hypertension.
PG  - 193-202
LID - 10.2463/mrms.mp.2015-0038 [doi]
AB  - PURPOSE: Institutional Review Board (IRB)-approved prospective study was 
      conducted to test whether objective and quantitative hemodynamic markers wall 
      shear stress (WSS) and oscillatory shear index (OSI) measured by 
      three-dimensional (3D) cine phase-contrast (PC) can reflect pulmonary arterial 
      hypertension (PAH). PATIENTS AND METHODS: Seventeen consecutive patients of 
      suspected secondary PAH were examined for pulmonary artery pressures (PAPs) with 
      right heart catheterization (RHC) and three-dimensional (3D) cine PC MR. Based on 
      the RHC data, patients were subdivided into two groups of 12 non-PAH (median age 
      of 74.5 years) and 5 PAH (median age of 77 years) patients. Based on 3D cine PC 
      magnetic resonance (MR), hemodynamic parameters including spatially averaged 
      systolic WSS (sWSS), diastolic WSS (dWSS), mean WSS (mWSS), OSI and blood vessel 
      section area (BVSA) at the pulmonary arterial trunk were calculated. Streamline 
      images in the pulmonary arteries were also assessed. All the parameters were 
      compared between non-PAH and PAH groups. RESULTS: sWSS (N/m(2)) and mWSS (N/m(2)) 
      of PAH group was lower than that of non-PAH group (0.594 +/- 0.067 vs. 0.961 +/- 
      0.590, P = 0.001), (0.365 +/- 0.035 vs. 0.489 +/- 0.132, P = 0.027). OSI of PAH group 
      was higher than that of non-PAH (0.214 +/- 0.026 vs. 0.130 +/- 0.046, P = 0.001). 
      sWSS, mWSS, and dWSS were inversely correlated and OSI was positively correlated 
      to mean PAP or systolic PAP with r values of -0.638 (P = 0.005), -0.643 (P = 
      0.005), -0.485 (P = 0.049), and 0.625 (P = 0.007); or -0.622 (P = 0.008), -0.629 
      (P = 0.007), -0.484 (P = 0.049), and 0.594 (P = 0.012), respectively. sWSS was 
      also inversely correlated to BVSA with r value of -0.488 (P = 0.049), and OSI was 
      correlated to BVSA with r value of 0.574 (P = 0.016). Vortex or helical flows 
      were observed more frequently in PAH patients. CONCLUSIONS: The low sWSS and mWSS 
      as well as high OSI measured with 3D cine PC MR could be potential hemodynamic 
      markers for the increased PAP in suspected secondary PAH patients.
FAU - Terada, Masaki
AU  - Terada M
AD  - Department of Diagnostic Radiological Technology, Iwata City Hospital.
FAU - Takehara, Yasuo
AU  - Takehara Y
FAU - Isoda, Haruo
AU  - Isoda H
FAU - Uto, Tomohiro
AU  - Uto T
FAU - Matsunaga, Masaki
AU  - Matsunaga M
FAU - Alley, Marcus
AU  - Alley M
LA  - eng
PT  - Journal Article
DEP - 20151113
PL  - Japan
TA  - Magn Reson Med Sci
JT  - Magnetic resonance in medical sciences : MRMS : an official journal of Japan 
      Society of Magnetic Resonance in Medicine
JID - 101153368
SB  - IM
MH  - Aged
MH  - Hemodynamics/physiology
MH  - Humans
MH  - *Hypertension, Pulmonary/diagnostic imaging/physiopathology
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - *Pulmonary Artery/diagnostic imaging/physiopathology
PMC - PMC5600056
EDAT- 2015/11/17 06:00
MHDA- 2016/12/15 06:00
PMCR- 2015/11/13
CRDT- 2015/11/17 06:00
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2015/11/13 00:00 [pmc-release]
AID - mrms-15-193 [pii]
AID - 10.2463/mrms.mp.2015-0038 [doi]
PST - ppublish
SO  - Magn Reson Med Sci. 2016;15(2):193-202. doi: 10.2463/mrms.mp.2015-0038. Epub 2015 
      Nov 13.