PMID- 26567842 OWN - NLM STAT- MEDLINE DCOM- 20170307 LR - 20170307 IS - 1884-2836 (Electronic) IS - 1344-6304 (Linking) VI - 69 IP - 4 DP - 2016 Jul 22 TI - Time-Series Analysis Comparing the Prevalence of Antibodies against Nine Viral Species Found in Umbilical Cord Blood in Japan. PG - 314-8 LID - 10.7883/yoken.JJID.2015.366 [doi] AB - In this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates in 2013. Serum IgG antibodies against the following viruses were measured: herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles virus (MV), rubella virus (RV), mumps virus (MuV), and human parvovirus B19 (HPV B19). A survey questionnaire regarding past medical history and maternal immunization status for the vaccine-preventable diseases of varicella, measles, rubella, and mumps was simultaneously administered. The results were compared with previous data collected in 2001-2002 from 378 umbilical cord blood samples. Viral seroprevalence data were: HSV, 54%; VZV, 96%; EBV, 96%; CMV, 67%; HHV-6, 100%; MV, 95%; RV, 94%; MuV, 64%; and HPV B19, 55%. The seroprevalence of CMV, MV, and MuV were significantly lower in 2013 than in 2001-2002 (CMV, 76%; MV, 98%; MuV, 93%). Compared with the 2001-2002 data, the mean IgG antibody values of the 4 vaccine-preventable diseases were significantly lower, and vaccination coverage for those diseases among mothers was significantly higher. Thus, attention should be paid to antibody levels in women of childbearing age in the future. FAU - Takemoto, Koji AU - Takemoto K AD - Department of Pediatrics, Konan Kosei Hospital. FAU - Nishimura, Naoko AU - Nishimura N FAU - Kozawa, Kei AU - Kozawa K FAU - Hibino, Hiromi AU - Hibino H FAU - Kawaguchi, Masahiro AU - Kawaguchi M FAU - Takeuchi, Suguru AU - Takeuchi S FAU - Fujishiro, Naozumi AU - Fujishiro N FAU - Arai, Sakiko AU - Arai S FAU - Gotoh, Kensei AU - Gotoh K FAU - Hosono, Haruki AU - Hosono H FAU - Ozaki, Takao AU - Ozaki T LA - eng PT - Journal Article DEP - 20151113 PL - Japan TA - Jpn J Infect Dis JT - Japanese journal of infectious diseases JID - 100893704 RN - 0 (Antibodies, Viral) RN - 0 (Immunoglobulin G) SB - IM MH - Adult MH - Antibodies, Viral/*blood MH - Cytomegalovirus/immunology/isolation & purification MH - Female MH - Fetal Blood/*immunology/virology MH - Herpesvirus 3, Human/immunology/isolation & purification MH - Herpesvirus 4, Human/immunology/isolation & purification MH - Herpesvirus 6, Human/immunology/isolation & purification MH - Humans MH - Immunoglobulin G/*blood MH - Infant, Newborn MH - Japan/epidemiology MH - Measles virus/immunology/isolation & purification MH - Mumps virus/immunology/isolation & purification MH - Parvovirus B19, Human/immunology/isolation & purification MH - Rubella virus/immunology/isolation & purification MH - Seroepidemiologic Studies MH - Simplexvirus/immunology/isolation & purification MH - Vaccination/*statistics & numerical data MH - Virus Diseases/*epidemiology/immunology/prevention & control/virology EDAT- 2015/11/17 06:00 MHDA- 2017/03/08 06:00 CRDT- 2015/11/17 06:00 PHST- 2015/11/17 06:00 [entrez] PHST- 2015/11/17 06:00 [pubmed] PHST- 2017/03/08 06:00 [medline] AID - 10.7883/yoken.JJID.2015.366 [doi] PST - ppublish SO - Jpn J Infect Dis. 2016 Jul 22;69(4):314-8. doi: 10.7883/yoken.JJID.2015.366. Epub 2015 Nov 13.