PMID- 26568005
OWN - NLM
STAT- MEDLINE
DCOM- 20160704
LR  - 20220331
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 54
IP  - 22
DP  - 2015
TI  - Light-Chain Deposition Disease Successfully Treated with Bortezomib in an Elderly 
      Patient: A Case Report and Review of the Literature.
PG  - 2893-8
LID - 10.2169/internalmedicine.54.4994 [doi]
AB  - We herein report the case of an elderly patient with light-chain deposition 
      disease (LCDD) successfully treated with bortezomib. An 83-year-old woman was 
      admitted because of nephrotic syndrome. She was diagnosed to have monoclonal 
      gammopathy of undetermined significance (IgG-kappa type) and LCDD, on the basis of 
      serum and urinary immunoelectrophoresis and renal biopsy. She responded to a 
      modified regimen of bortezomib-based chemotherapy with disappearance of 
      proteinuria without any adverse effects. According to a literature review of 16 
      cases, including the present case, bortezomib-based chemotherapy appears to be a 
      convincing strategy for the treatment of LCDD even in elderly patients.
FAU - Wada, Yukihiro
AU  - Wada Y
AD  - Division of Nephrology, Department of Medicine, Showa University School of 
      Medicine, Japan.
FAU - Iyoda, Masayuki
AU  - Iyoda M
FAU - Saito, Tomohiro
AU  - Saito T
FAU - Arai-Nunota, Noriko
AU  - Arai-Nunota N
FAU - Iseri, Ken
AU  - Iseri K
FAU - Tomita, Eiko
AU  - Tomita E
FAU - Ikeda, Misa
AU  - Ikeda M
FAU - Yamaguchi, Yutaka
AU  - Yamaguchi Y
FAU - Shibata, Takanori
AU  - Shibata T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20151115
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 69G8BD63PP (Bortezomib)
SB  - IM
MH  - Aged, 80 and over
MH  - Antineoplastic Agents, Alkylating/*therapeutic use
MH  - Bortezomib/*therapeutic use
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Monoclonal Gammopathy of Undetermined Significance/*diagnosis/pathology
MH  - Nephrotic Syndrome/*etiology/pathology/urine
MH  - Proteinuria/*etiology
MH  - Remission Induction
MH  - Treatment Outcome
EDAT- 2015/11/17 06:00
MHDA- 2016/07/05 06:00
CRDT- 2015/11/17 06:00
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/07/05 06:00 [medline]
AID - 10.2169/internalmedicine.54.4994 [doi]
PST - ppublish
SO  - Intern Med. 2015;54(22):2893-8. doi: 10.2169/internalmedicine.54.4994. Epub 2015 
      Nov 15.