PMID- 26569416
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1439-0795 (Electronic)
IS  - 0176-3679 (Linking)
VI  - 49
IP  - 1
DP  - 2016 Jan
TI  - Expression of Glutamate Transporters in Alcohol Withdrawal.
PG  - 14-7
LID - 10.1055/s-0035-1565134 [doi]
AB  - INTRODUCTION: The study aimed to investigate the expression of glutamate 
      transporters during withdrawal in the alcohol-dependent patients. METHOD: The 
      study consisted of 20 male inpatient alcoholics during the withdrawal period and 
      20 healthy controls. Expressions of glutamate transporters, namely the excitatory 
      amino acid transporter 2 (EAAT2) and EAAT3, in white blood cells were measured 
      with the real-time polymerase chain reaction (RT-PCR) method in early (first day) 
      and late (28(th) day) withdrawal in alcoholic patients and once in the controls. 
      RESULTS: EAAT2 and EAAT3 expressions in the patients during both early and late 
      withdrawal were higher than those of the controls. There was no difference in the 
      EAAT2 and EAAT3 levels of the patients between early and late abstinence. 
      DISCUSSION: The study revealed an upregulation of glutamate transporters EAAT2 
      and EAAT3 during early and late withdrawal in patients with alcohol withdrawal.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Ozsoy, S
AU  - Ozsoy S
AD  - Department of Psychiatry, Erciyes University School of Medicine, Kayseri/Turkey.
FAU - Asdemir, A
AU  - Asdemir A
AD  - Department of Psychiatry, Erciyes University School of Medicine, Kayseri/Turkey.
FAU - Karaaslan, O
AU  - Karaaslan O
AD  - Department of Psychiatry, Yozgat State Hospital, Yozgat/Turkey.
FAU - Akalin, H
AU  - Akalin H
AD  - Department of Medical Genetics, Erciyes University School of Medicine, 
      Kayseri/Turkey.
FAU - Ozkul, Y
AU  - Ozkul Y
AD  - Department of Medical Genetics, Erciyes University School of Medicine, 
      Kayseri/Turkey.
FAU - Esel, E
AU  - Esel E
AD  - Department of Psychiatry, Erciyes University School of Medicine, Kayseri/Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151116
PL  - Germany
TA  - Pharmacopsychiatry
JT  - Pharmacopsychiatry
JID - 8402938
RN  - 0 (Amino Acid Transport System X-AG)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcoholism/*metabolism/*physiopathology
MH  - Amino Acid Transport System X-AG/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Statistics, Nonparametric
MH  - Substance Withdrawal Syndrome/*metabolism
EDAT- 2015/11/17 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/11/17 06:00
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.1055/s-0035-1565134 [doi]
PST - ppublish
SO  - Pharmacopsychiatry. 2016 Jan;49(1):14-7. doi: 10.1055/s-0035-1565134. Epub 2015 
      Nov 16.