PMID- 26569460
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20220316
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 13
IP  - 3
DP  - 2016 Mar
TI  - Lack of regional association between atrial late gadolinium enhancement on 
      cardiac magnetic resonance and atrial fibrillation rotors.
PG  - 654-60
LID - S1547-5271(15)01397-1 [pii]
LID - 10.1016/j.hrthm.2015.11.011 [doi]
AB  - BACKGROUND: The extent of left atrial (LA) late gadolinium enhancement (LGE), as 
      a surrogate for fibrosis, has been associated with atrial fibrillation (AF) 
      recurrence after catheter ablation. Furthermore, there is ex vivo evidence that 
      islands of fibrosis may anchor fibrillatory rotors. OBJECTIVE: The purpose of 
      this study was to examine the anatomical association of AF rotors with LA and 
      right atrial (RA) LGE on cardiac magnetic resonance. METHODS: The cohort included 
      9 patients with persistent AF (mean age 61.1 +/- 9.7 years) who underwent LGE 
      cardiac magnetic resonance before AF ablation using the focal impulse and rotor 
      modulation system. The extent of LA and RA LGE was quantified globally and in 
      each of the 7 sectors: LA posterior/inferior wall, anterior wall, roof, left and 
      right pulmonary vein antra, and RA lateral and septal regions. The multivariable 
      association of rotor incidence with global and per sector LGE extent was examined 
      using multivariable Bernoulli logistic regression estimated by generalized 
      estimating equations. RESULTS: The mean RA and LA volumes were 113.2 +/- 37.31 and 
      143.03 +/- 58.25 mL, respectively. The mean RA and LA LGE burden was 17.2% +/- 11.0% 
      and 17.4% +/- 14.4%, respectively. A total of 18 LA rotors and 9 RA rotors were 
      identified in all patients. No univariable or multivariable association was 
      observed between global or per sector LGE extent and focal impulse and rotor 
      modulation rotor incidence. CONCLUSION: In this cohort of patients, there was no 
      association between AF rotor incidence and the global or regional extent of RA 
      and LA LGE.
CI  - Copyright (c) 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Chrispin, Jonathan
AU  - Chrispin J
AD  - Department of Cardiology. Electronic address: chrispin@jhmi.edu.
FAU - Gucuk Ipek, Esra
AU  - Gucuk Ipek E
AD  - Department of Cardiology.
FAU - Zahid, Sohail
AU  - Zahid S
AD  - Department of Biomedical Engineering.
FAU - Prakosa, Adityo
AU  - Prakosa A
AD  - Department of Biomedical Engineering.
FAU - Habibi, Mohammadali
AU  - Habibi M
AD  - Department of Cardiology.
FAU - Spragg, David
AU  - Spragg D
AD  - Department of Cardiology.
FAU - Marine, Joseph E
AU  - Marine JE
AD  - Department of Cardiology.
FAU - Ashikaga, Hiroshi
AU  - Ashikaga H
AD  - Department of Cardiology.
FAU - Rickard, John
AU  - Rickard J
AD  - Department of Cardiology.
FAU - Trayanova, Natalia A
AU  - Trayanova NA
AD  - Department of Biomedical Engineering.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - Department of Radiolog.
FAU - Zipunnikov, Vadim
AU  - Zipunnikov V
AD  - Department of Biostatistics.
FAU - Berger, Ronald D
AU  - Berger RD
AD  - Department of Cardiology; Department of Biomedical Engineering.
FAU - Calkins, Hugh
AU  - Calkins H
AD  - Department of Cardiology.
FAU - Nazarian, Saman
AU  - Nazarian S
AD  - Department of Cardiology; Department of Epidemiology, Johns Hopkins University 
      School of Medicine, Baltimore, Maryland.
LA  - eng
GR  - 5T32HL007227-38/HL/NHLBI NIH HHS/United States
GR  - K23HL089333/HL/NHLBI NIH HHS/United States
GR  - R01HL116280/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151110
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Atrial Fibrillation/*diagnosis/physiopathology/surgery
MH  - Atrial Function, Left/*physiology
MH  - Catheter Ablation
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium/*pharmacology
MH  - Heart Atria/*diagnostic imaging/physiopathology
MH  - Heart Conduction System/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Time Factors
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Delayed enhancement magnetic resonance imaging
OT  - Fibrosis
OT  - Rotor
EDAT- 2015/11/17 06:00
MHDA- 2016/12/24 06:00
CRDT- 2015/11/17 06:00
PHST- 2015/08/25 00:00 [received]
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
AID - S1547-5271(15)01397-1 [pii]
AID - 10.1016/j.hrthm.2015.11.011 [doi]
PST - ppublish
SO  - Heart Rhythm. 2016 Mar;13(3):654-60. doi: 10.1016/j.hrthm.2015.11.011. Epub 2015 
      Nov 10.