PMID- 26571174
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220331
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Print)
IS  - 0362-2436 (Linking)
VI  - 41
IP  - 3
DP  - 2016 Feb
TI  - The Health Impact of Symptomatic Adult Spinal Deformity: Comparison of Deformity 
      Types to United States Population Norms and Chronic Diseases.
PG  - 224-33
LID - 10.1097/BRS.0000000000001202 [doi]
AB  - STUDY DESIGN: A retrospective analysis of a prospective, multicenter database. 
      OBJECTIVE: The aim of this study was to evaluate the health impact of symptomatic 
      adult spinal deformity (SASD) by comparing Standard Form Version 2 (SF-36) scores 
      for SASD with United States normative and chronic disease values. SUMMARY OF 
      BACKGROUND DATA: Recent data have identified radiographic parameters correlating 
      with poor health-related quality of life for SASD. Disability comparisons between 
      SASD patients and patients with chronic diseases may provide further insight to 
      the disease burden caused by SASD. METHODS: Consecutive SASD patients, with no 
      history of spine surgery, were enrolled into a multicenter database and evaluated 
      for type and severity of spinal deformity. Baseline SF-36 physical component 
      summary (PCS) and mental component summary (MCS) values for SASD patients were 
      compared with reported U.S. normative and chronic disease SF-36 scores. SF-36 
      scores were reported as normative-based scores (NBS) and evaluated for minimally 
      clinical important difference (MCID). RESULTS: Between 2008 and 2011, 497 SASD 
      patients were prospectively enrolled and evaluated. Mean PCS for all SASD was 
      lower than U.S. total population (ASD = 40.9; US = 50; P < 0.05). Generational 
      decline in PCS for SASD patients with no other reported comorbidities was more 
      rapid than U.S. norms (P < 0.05). PCS worsened with lumbar scoliosis and 
      increasing sagittal vertical axis (SVA). PCS scores for patients with isolated 
      thoracic scoliosis were similar to values reported by individuals with chronic 
      back pain (45.5 vs 45.7, respectively; P > 0.05), whereas patients with lumbar 
      scoliosis combined with severe sagittal malalignment (SVA >10 cm) demonstrated 
      worse PCS scores than values reported by patients with limited use of arms and 
      legs (24.7 vs 29.1, respectively; P < 0.05). CONCLUSIONS: SASD is a heterogeneous 
      condition that, depending upon the type and severity of the deformity, can have a 
      debilitating impact on health often exceeding the disability of more recognized 
      chronic diseases. Health care providers must be aware of the types of SASD that 
      correlate with disability to facilitate appropriate diagnosis, treatment, and 
      research efforts. LEVEL OF EVIDENCE: 3.
FAU - Bess, Shay
AU  - Bess S
AD  - *Rocky Mountain Hospital for ChildrendaggerRocky Mountain Scoliosis & Spine, Denver, 
      COdouble daggerCornell University School of Medicine, New York, NY section signEmory University, 
      Department of Economics, Atlanta, GA||New York University School of Medicine, 
      Department of Orthopedic Surgery, New York, NY paragraph signUniversity of Virginia School of 
      Medicine, Department of Neurosurgery, Charlottesville, VA#University of 
      California San Francisco School of Medicine, Department of Neurosurgery, San 
      Francisco**San Diego Center for Spinal Disorders, La Jolla, CAdaggerdaggerHospital for 
      Special Surgery, Department of Orthopedic Surgery, New York, NYdouble daggerdouble daggerWashington 
      University, Saint Louis, MO section sign section signUniversity of Kansas School of Medicine, Department 
      of Orthopedic Surgery, Kansas City, KS||||University of Oregon School of 
      Medicine, Department of Orthopedic Surgery, Portland, OR paragraph sign paragraph signUniversity of 
      California Davis School of Medicine, Department of Orthopedic Surgery, 
      Sacramento, CA##Johns Hopkins University School of Medicine, Department of 
      Orthopedic Surgery, Baltimore, MD***Baylor Scoliosis Center, Plano, TX.
FAU - Line, Breton
AU  - Line B
FAU - Fu, Kai-Ming
AU  - Fu KM
FAU - McCarthy, Ian
AU  - McCarthy I
FAU - Lafage, Virgine
AU  - Lafage V
FAU - Schwab, Frank
AU  - Schwab F
FAU - Shaffrey, Christopher
AU  - Shaffrey C
FAU - Ames, Christopher
AU  - Ames C
FAU - Akbarnia, Behrooz
AU  - Akbarnia B
FAU - Jo, Han
AU  - Jo H
FAU - Kelly, Michael
AU  - Kelly M
FAU - Burton, Douglas
AU  - Burton D
FAU - Hart, Robert
AU  - Hart R
FAU - Klineberg, Eric
AU  - Klineberg E
FAU - Kebaish, Khaled
AU  - Kebaish K
FAU - Hostin, Richard
AU  - Hostin R
FAU - Mundis, Gregory
AU  - Mundis G
FAU - Mummaneni, Praveen
AU  - Mummaneni P
FAU - Smith, Justin S
AU  - Smith JS
CN  - International Spine Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Population Surveillance
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Spinal Diseases/*diagnostic imaging/*epidemiology
MH  - United States/epidemiology
PMC - PMC4718181
EDAT- 2015/11/17 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/01/19
CRDT- 2015/11/17 06:00
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/01/19 00:00 [pmc-release]
AID - 10.1097/BRS.0000000000001202 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2016 Feb;41(3):224-33. doi: 10.1097/BRS.0000000000001202.