PMID- 26571453
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20191210
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1007
DP  - 2015 Dec 15
TI  - Single-step microwave assisted headspace liquid-phase microextraction of 
      trihalomethanes and haloketones in biological samples.
PG  - 43-8
LID - S1570-0232(15)30266-X [pii]
LID - 10.1016/j.jchromb.2015.11.004 [doi]
AB  - A single-step microwave assisted headspace liquid-phase microextraction 
      (MA-HS-LPME) method was developed for determination of trihalomethanes (THMs) and 
      haloketones (HKs) in biological samples. In this method, a porous membrane 
      envelope was filled with few microliters of extraction solvent and then placed 
      inside the microwave extraction vial. A PTFE ring was designed to support the 
      membrane envelope over a certain height inside the vial. An optimum amount of 
      biological sample was placed in the vial equipped with magnetic stirrer. After 
      that nitric acid was added to the vial for digestion of biological sample. The 
      sample was digested and the volatile THMs and HKs were extracted at headspace in 
      the solvent containing porous membrane. After simultaneous digestion and 
      extraction, the extract was injected to gas chromatography/mass spectrometry for 
      analysis. Factors affecting the extraction efficiency were optimized to achieve 
      higher extraction performance. Quantification was carried out over a 
      concentration range of 0.3-100ngg(-1) for brominated compounds while for the 
      chlorinated ones linear range was between 0.5-100ngg(-1). Limit of detections 
      (LODs) were ranged from 0.051 to 0.110ngg(-1) while limit of quantification (LOQ) 
      were in the range of 0.175-0.351ngg(-1). The relative standard deviations (RSDs) 
      of the calibrations were ranged between 1.1 and 6.8%. The MA-HS-LPME was applied 
      for the determination of trace level THMs and HKs in fish tissue and green alga 
      samples.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Alsharaa, Abdulnaser
AU  - Alsharaa A
AD  - Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 
      31261, Saudi Arabia.
FAU - Basheer, Chanbasha
AU  - Basheer C
AD  - Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 
      31261, Saudi Arabia; Center of Excellence in Nanotechnology, King Fahd University 
      of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. Electronic address: 
      cbasheer@kfupm.edu.sa.
FAU - Sajid, Muhammad
AU  - Sajid M
AD  - Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 
      31261, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20151104
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Ketones)
RN  - 0 (Trihalomethanes)
SB  - IM
MH  - Animals
MH  - Fishes
MH  - Gas Chromatography-Mass Spectrometry
MH  - Ketones/*analysis
MH  - Limit of Detection
MH  - Liquid Phase Microextraction/*methods
MH  - *Microwaves
MH  - Trihalomethanes/*analysis
OTO - NOTNLM
OT  - Disinfection by-products
OT  - Environmental applications
OT  - Gas chromatography-
OT  - Microwave assisted headspace liquid-phase microextraction
OT  - mass spectrometry
EDAT- 2015/11/17 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/11/17 06:00
PHST- 2015/08/15 00:00 [received]
PHST- 2015/10/30 00:00 [revised]
PHST- 2015/11/01 00:00 [accepted]
PHST- 2015/11/17 06:00 [entrez]
PHST- 2015/11/17 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - S1570-0232(15)30266-X [pii]
AID - 10.1016/j.jchromb.2015.11.004 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:43-8. doi: 
      10.1016/j.jchromb.2015.11.004. Epub 2015 Nov 4.