PMID- 26572604
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20181113
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 54
IP  - 10
DP  - 2016 Oct
TI  - Characteristics of C6-7 myelopathy: assessment of clinical symptoms and 
      electrophysiological findings.
PG  - 798-803
LID - 10.1038/sc.2015.203 [doi]
AB  - STUDY DESIGN: This is a single-center retrospective study. OBJECTIVES: The 
      objective of this study was to study the clinical symptoms and 
      electrophysiological features of C6-7 myelopathy. SETTING: This study was 
      conducted at the Department of Orthopedic surgery, Yamaguchi University Graduate 
      school of medicine, Japan. METHODS: A total of 20 patients with cervical 
      compressive myelopathy were determined by spinal cord-evoked potentials or a 
      single level of obvious magnetic resonance imaging (MRI)-documented cervical 
      spinal cord compression. Neurological examinations included manual muscle testing 
      and investigation of deep tendon reflex, including Hoffmann sign, and of sensory 
      disturbance areas. Motor-evoked potentials (MEPs), compound muscle action 
      potentials (CMAPs) and F-wave were recorded from bilateral abductor digit minim 
      and abductor halluces muscles. Central motor conduction time was calculated as 
      follows: MEPs latency-(CMAPs latency+F latency-1)/2 (ms). RESULTS: Eighteen 
      patients (90%) had negative Hoffmann sign. Eight patients (40%) had no sensory 
      disturbance in the upper limbs and 8 patients (40%) had no muscle weakness in the 
      upper limbs. We determined that patients had cervical myelopathy when their 
      central motor conduction time measured in abductor digit minim was longer than 
      6.76 ms (+2 s.d.). Using this definition, the sensitivity for myelopathy was 
      42.8%. CONCLUSION: Patients with C6-7 myelopathy may lack clinical symptoms in 
      their hands and central motor conduction time measured in abductor digit minim 
      tended to be less prolonged, and it only showed symptoms in their lower limbs as 
      gait disturbance. Surgeons should bear in mind the possibility of disorders of 
      caudal C6-7 when they encounter patients with no or few symptoms in their hands 
      and with leg weakness or numbness.
FAU - Funaba, M
AU  - Funaba M
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Kanchiku, T
AU  - Kanchiku T
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Imajo, Y
AU  - Imajo Y
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Suzuki, H
AU  - Suzuki H
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Yoshida, Y
AU  - Yoshida Y
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Nishida, N
AU  - Nishida N
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Fujimoto, K
AU  - Fujimoto K
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
FAU - Taguchi, T
AU  - Taguchi T
AUID- ORCID: 0000-0003-1802-3473
AD  - Department of Orthopedic Surgery, Yamaguchi University Graduate School of 
      Medicine, Ube city, Japan.
LA  - eng
PT  - Journal Article
DEP - 20151117
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cervical Vertebrae/diagnostic imaging/*pathology
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle Fatigue/physiology
MH  - Muscle, Skeletal/physiopathology
MH  - Neural Conduction/*physiology
MH  - Neurologic Examination
MH  - Reaction Time/physiology
MH  - Retrospective Studies
MH  - Spinal Cord Injuries/diagnostic imaging/*physiopathology
MH  - Statistics, Nonparametric
MH  - Young Adult
EDAT- 2015/11/18 06:00
MHDA- 2017/07/14 06:00
CRDT- 2015/11/18 06:00
PHST- 2015/05/31 00:00 [received]
PHST- 2015/10/04 00:00 [revised]
PHST- 2015/10/13 00:00 [accepted]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2015/11/18 06:00 [entrez]
AID - sc2015203 [pii]
AID - 10.1038/sc.2015.203 [doi]
PST - ppublish
SO  - Spinal Cord. 2016 Oct;54(10):798-803. doi: 10.1038/sc.2015.203. Epub 2015 Nov 17.