PMID- 26572772
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20181202
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 44
IP  - 6
DP  - 2015 Nov-Dec
TI  - Comparison of different strategies for acute ST-segment elevation myocardial 
      infarction with high thrombus burden in clinical practice: Symptom-free outcome 
      at one year.
PG  - 487-93
LID - S0147-9563(15)00215-0 [pii]
LID - 10.1016/j.hrtlng.2015.08.003 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the clinical effects of 
      different strategies for preventing coronary microvascular obstruction in ST 
      elevation myocardial infarction (STEMI) patients with a high thrombus-burden 
      plaque. METHODS: Between January, 2007 and December, 2012, 354 patients suffering 
      from STEMI with high thrombus-burden were enrolled and divided into three groups 
      as the first group received a GP IIb/IIIa inhibitor, and the second group 
      received a distal protective device, and the third group was treated with primary 
      PCI alone. RESULTS: A high percentage of patients in the GP IIb/IIIa inhibitor 
      (96.8% and 90.5%), distal protective device (99.3% and 87.6%) had better 
      thirty-day and one-year symptom-free outcomes when compared with PCI only group 
      (91.6% and 65.6%) (P = 0.008 and P < 0.001; respectively). CONCLUSIONS: Treatment 
      with intracoronary GP IIb/IIIa inhibitor injection or distal protection device to 
      prevent coronary microvascular obstruction was demonstrated to increase the 
      occurrences of thirty-day and one-year symptom-free outcomes; thus, these 
      treatments can help decrease post-MI medical care costs.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Lee, Wei-Chieh
AU  - Lee WC
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Chen, Huang-Chung
AU  - Chen HC
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Fang, Hsiu-Yu
AU  - Fang HY
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Hsueh, Shu-Kai
AU  - Hsueh SK
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Chen, Chien-Jen
AU  - Chen CJ
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Yang, Cheng-Hsu
AU  - Yang CH
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Yip, Hon-Kan
AU  - Yip HK
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Wu, Chiung-Jen
AU  - Wu CJ
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC. Electronic address: leeweichieh1217@hotmail.com.
FAU - Fang, Chih-Yuan
AU  - Fang CY
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
FAU - Hang, Chi-Ling
AU  - Hang CL
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 
      ROC.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 42HK56048U (Tyrosine)
RN  - GGX234SI5H (Tirofiban)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Thrombosis/etiology/*prevention & control
MH  - Dose-Response Relationship, Drug
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Injections, Intra-Arterial
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*therapy
MH  - Percutaneous Coronary Intervention
MH  - Platelet Aggregation Inhibitors/administration & dosage
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors
MH  - Tirofiban
MH  - Tyrosine/administration & dosage/*analogs & derivatives
OTO - NOTNLM
OT  - Distal protection device
OT  - GP IIb/IIIa receptor inhibitor
OT  - High thrombus-burden plaque
OT  - Primary percutaneous coronary intervention
OT  - ST elevation myocardial infarction
OT  - Symptom-free outcomes
EDAT- 2015/11/18 06:00
MHDA- 2016/06/15 06:00
CRDT- 2015/11/18 06:00
PHST- 2015/03/28 00:00 [received]
PHST- 2015/08/14 00:00 [revised]
PHST- 2015/08/15 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
AID - S0147-9563(15)00215-0 [pii]
AID - 10.1016/j.hrtlng.2015.08.003 [doi]
PST - ppublish
SO  - Heart Lung. 2015 Nov-Dec;44(6):487-93. doi: 10.1016/j.hrtlng.2015.08.003.